The Hh blood group contains one antigen, the H antigen, which is found on virtually all RBCs and is the building block for the production of the antigens within the ABO blood group. H antigen deficiency is known as the "Bombay phenotype" (h/h, also known as Oh) and is found in 1 of 10,000 individuals in India and 1 in a million people in Europe.

Also known as substance H, H antigen is a precursor to each of the ABO blood group antigens, apparently present in all people except those with the Bombay Blood phenotype [1] (see hh blood group). The gene responsible for making H antigen is …

hh, [1] or the Bombay blood group, is a rare blood type. This blood phenotype was first discovered in Bombay by Dr. Y. M. Bhende in 1952. It is mostly found in the Indian subcontinent (India, Bangladesh, Pakistan) and Iran.

2024年9月11日 · The H gene encodes an enzyme that is required in the expression of the H antigen on the surface of red blood cells. Translation of the active allele, H, of the FUT1 gene results in formation of the enzyme known as α-1,2-fucosyltransferase (H is also known as FUT1 because the gene product is a FUcosyl Transferase). This enzyme acts to transfer ...

The H antigen defines the O blood group and is the precursor for A and B antigens. The gene H(FUT1) on chromosome 19 encodes a fucosyltransferase preferentially expressed in erythroid cells which adds a fucose in α (1,2) linkage on type 2 …

2023年12月20日 · What is the h gene? The h gene, also known as the human gene, is a key player in regulating various biological processes. It encodes for proteins that play crucial roles in cell growth, development, and differentiation. Mutations in the h gene have been linked to a wide range of disorders, including genetic diseases and cancers.

2024年9月11日 · H Antigen A short sequence of sugars (oligosaccharide) found on many cells in the human body, but especially attached to red blood cell membranes and floating free in plasma and secretions.

Background and objectives: Formal genetics of ABO, H-h and Se-se systems illustrate that these three systems are genetically independent. Materials and methods: Population analysis of phenotypes and family segregation of the ABH related genetic markers.

in laboratory animals, a gene that can elicit an immune response and thereby cause rejection of a homograft when tissue is transplanted from one individual to another; in humans, histocompatibility genes control HLA antigens. Synonym (s): H gene.

There are only two recognized alleles at this locus—the active form, H, and an amorph, h. The H gene is a high-incidence gene. People who inherit hh are extremely rare. Since the h gene is amorphic, it does not act on the precursor substance. The H gene can convert the precursor substance to the H substance. The hh gene, as an amorph, cannot.