H19 is a gene for a long noncoding RNA, found in humans and elsewhere. H19 has a role in the negative regulation (or limiting) of body weight and cell proliferation. [3] . This gene also has a role in the formation of some cancers and in the regulation of gene expression. [4]

2024年12月25日 · H19 (H19 Imprinted Maternally Expressed Transcript) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with H19 include Hemihyperplasia, Isolated and Embryonal Carcinoma . Among its related pathways is ncRNAs involved in Wnt signaling in hepatocellular carcinoma .

H19/Igf2印迹基因隶属于一个基因印迹群，分别位于人染色体11P15．5，鼠7号染色体，在进化上具有高度的保守性。 H19基因为母源性印迹基因，而Igf2基因为父源性印迹基因，两者相距90kb，皆受H19基因上游4kb处 差异甲基化区 （differentiallymethylatedregion，DMR）或印记 ...

h19是一个人类和其它动物中发现的长链非编码rna 基因 [3] ，h19是一种抑癌基因，能抑制细胞增殖和一些癌症相关基因的表达 [4] 。

2024年2月14日 · Long noncoding RNA H19 (H19) was one of the first lncRNAs encoded by H19 [3]. The H19 gene is 2.5 kb in length and is located on chromosome 11p15.5, with five exons and four introns. H19...

The H19 gene provides instructions for making a molecule of RNA, a chemical cousin of DNA. Learn about this gene and related health conditions.

Mechanistically, H19 mediates diverse regulatory functions by serving as competing endogenous RNAs (CeRNAs), Igf2/H19 imprinted tandem gene, modular scaffold, cooperating with H19 antisense, and acting directly with other mRNAs or lncRNAs.

H19 (Gene) is a long non-coding RNA abundantly expressed during embryonic development and downregulated after birth. It plays a role as a tumor suppressor gene, a trans regulator of co-expressed genes, and influences fetal growth, myogenesis, stem cell quiescence, human imprinting syndromes, and male infertility.

目前已有研究证实H19的低表达与 骨肉瘤 的进展和不良预后有关。而在乳腺癌、 胃肠道肿瘤 、 肺癌 、泌尿道肿瘤等肿瘤中H19高表达与局部侵袭、转移和预后不良有关。 四、H19在干细胞定向分化中的作用 H19在干细胞定向分化的过程中发挥了重要的调控作用。在 ...

Long non-coding RNAs (lncRNAs) have recently been found to be important in gene regulation. lncRNA H19 has been reported to play an oncogenic role in many human cancers. Its specific regulatory role is still elusive. In this study, we developed a ...

The H19 gene encodes a 2.3-kb non-coding mRNA which is strongly expressed during embryogenesis. This gene belongs to an imprinted cluster, conserved on mouse chromosome 7 and human chromosome 11p15. H19 is maternally expressed and the neighbouring Igf2 gene is transcribed from the paternal allele.

从机制上讲， H19通过充当竞争性内源RNA（CeRNA）、 Igf2/H19印记串联基因、模块化支架、与H19反义配合以及直接与其他mRNA或lncRNA发挥作用来介导多种调节功能。

The H19 gene produces a non-coding RNA, which is abundantly expressed during embryonic development and down-regulated after birth. Although this gene was discovered over 20 years ago, its function has remained unclear. Only recently a role was identified for the non-coding RNA and/or its microRNA pa …

2015年12月21日 · We show that H19 knockdown activates SAHH, leading to increased DNMT3B-mediated methylation of an lncRNA-encoding gene Nctc1 within the Igf2-H19-Nctc1 locus. Genome-wide methylation profiling...

2023年7月28日 · LncRNA H19 has been linked to endometriosis, diminished ovarian reserve, polycystic ovary syndrome, uterine fibroids, and male factor infertility. 3. The clinical implications of lncRNA H19 in...

2013年12月2日 · Here, we identified the methyl-CpG–binding domain protein 1 MBD1 as a physical and functional partner of the H19 long noncoding RNA (lncRNA). The H19 lncRNA–MBD1 complex is required for the control of five genes of the IGN.

2007年9月5日 · H19 is an imprinted gene that demonstrates maternal monoallelic expression without a protein product; although its expression is shut off in most tissues postnatally, it is re-activated during adult tissue regeneration and tumorigenesis. Moreover, H19 is highly expressed in liver metastasis derived from a range of carcinomas.

2020年10月26日 · H19 usually controls gene expression by acting as a microRNA sponge, or through mir-675, or by leading various protein complexes to genes at the chromosome level. The regulatory gene network has been intensively studied, whereas the biogenesis of H19 remains largely unknown.

2020年9月4日 · In this study, we developed a novel analytic approach by integrating the synergistic regulation among lncRNAs (e.g., H19), transcription factors (TFs), target genes, and microRNAs (miRNAs) and then applied it to the pan-cancer expression datasets from The Cancer Genome Atlas (TCGA).

2006年3月30日 · The H19 gene encodes a 2.3-kb non-coding mRNA which is strongly expressed during embryogenesis. This gene belongs to an imprinted cluster, conserved on mouse chromosome 7 and human chromosome 11p15. H19 is maternally expressed and the neighbouring Igf2 gene is transcribed from the paternal allele.