Establishment of BALB/C mouse models of influenza A H1N1 ... - PubMed
In this study, BALB/C mouse models of H1N1 virus aerosol inhalation were successfully established and compared with mouse models of intranasal inoculation, aerosol mouse …
Adaptation of Pandemic H1N1 Influenza Viruses in Mice - PMC
We, therefore, investigated the adaptation of two pandemic isolates, A/CA/04/09 (H1N1) and A/TN/1-560/09 (H1N1), which are not lethal for mice, to a new mammalian host. We used wild …
Fuzheng Jiedu decoction alleviates H1N1 virus-induced acute …
2025年2月11日 · Hyperactivation of the NLRP3 inflammasome is a key pathway leading to cytokine storm during H1N1 virus infection. Fuzheng Jiedu decoction treatment alleviated …
Single-cell transcriptomic analysis reveals the commonality of …
2024年10月31日 · These results suggest that humans and mice exhibit common immune responses to H1N1 infection, underscoring the similarity of vital immune mechanisms across …
Tmprss2 Is Essential for Influenza H1N1 Virus Pathogenesis in Mice …
2013年12月5日 · Here, we show that deletion of a single HA-activating protease gene, Tmprss2, in mice inhibits spread of mono-basic H1N1 influenza viruses, including the pandemic 2009 …
H1N1 nanobody development and therapeutic efficacy verification in H1N1 ...
2024年7月1日 · Here, we developed therapeutic nanobody against the H1N1 pandemic 2009 (A/California/04/2009; CA/04) and verified its effectiveness and safety through mice …
Establishment of BALB/C mouse models of influenza A H1N1 …
2019年7月18日 · Influenza A (H1N1) is a rapidly spreading acute respiratory illness that remains a worldwide burden on public health. To simulate natural infection routes, BALB/C mice were …
[Expression of influenza A H1N1 and H3N2 viruses Mosaic-HA1
2024年11月25日 · Enzyme-linked immunosorbent assay showed that Mosaic-HA1 induced the production of IgG targeting two types of HA1, the specific IgG titers for binding to H3 protein …
Adaptation of pandemic H1N1 influenza viruses in mice
The resulting mouse lung-adapted variants showed significantly enhanced growth characteristics in eggs, extended extrapulmonary tissue tropism, and pathogenicity in mice. All mouse …
Mouse Models of Influenza Infection with Circulating Strains to …
Infection with circulating H1N1 and representative influenza B viruses induced a dose-dependent disease response; however, a recent seasonal H3N2 virus did not cause any disease in mice, …