The H1 receptor is a histamine receptor belonging to the family of rhodopsin-like G-protein-coupled receptors. This receptor is activated by the biogenic amine histamine. It is expressed in smooth muscles, on vascular endothelial cells, in the heart, and in the central nervous system.

Histamine H 1 receptor (H 1 R) is a GPCR involved in type I hypersensitivity allergic reactions resulting from various allergens [91]. H 1 R is expressed in various tissues throughout the body [91] and it is highly expressed in ECs, where its expression level is higher than that in smooth muscle cells [92].

2024年1月2日 · Histamine receptors are a group of G protein-coupled receptors (GPCRs) that play important roles in various physiological and pathophysiological conditions. Antihistamines that target the...

Histamine and its receptors (H1R–H4R) play a crucial and significant role in the development of various allergic diseases. Mast cells are multifunctional bone marrow-derived tissue-dwelling cells that are the major producer of histamine in the body.

2024年12月25日 · HRH1 (Histamine Receptor H1) is a Protein Coding gene. Diseases associated with HRH1 include Allergic Rhinitis and Chronic Urticaria. Among its related pathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors).

Histamine H 1 receptor (H1R) is one of the targets of histamine in the nervous system and the peripheral tissues. Protein kinase Cδ (PKCδ) signaling is involved in histamine-induced upregulation of H1R gene expression in HeLa cells. Histamine also upregulates H1R gene expression in U-373 MG cells.

2021年4月7日 · Here, we present the cryo-electron microscopy (cryo-EM) structure of the human H1R in complex with a Gq protein in an active conformation via a NanoBiT tethering strategy.

是一种属于视紫红质样G蛋白偶联受体家族的受体，可被 组胺 激活。 它在平滑肌、血管内皮细胞、心脏、中枢神经系统中表达。 H1受体与细胞内G 蛋白的 Gαq亚基 （英语：Gq_alpha_subunit） 连接，激活 磷脂酶C 和 肌醇三磷酸 （IP3）信号通路。 作用于该受体的抗组胺药被用作抗过敏药物。 该受体的晶体结构已确定 [6] 并用于在基于结构的虚拟筛选研究中发现新的组胺H 受体配 …

2025年1月4日 · H1R; H1-R; HH1R; hisH1 Summary Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily.

2024年1月15日 · Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily.

The histamine 1 receptor (H1R) is widely distributed in various body tissues, including the endothelium, immune cells, and smooth muscle, and plays a crucial role in regulating vasodilation, atrial muscle contractility, and bronchoconstriction .

Histamine-activated histamine H 1 receptor (H1R) signaling regulates many gene expressions, mainly through the protein kinase C (PKC)/extracellular signal-regulated kinases (ERK) signaling. Involvement of other signaling, including NF-κB, Wnt, RUNX-2, …

2025年1月4日 · H1R, which is widely distributed in the body in epithelial cells and smooth vascular, neuronal, glial and immune cells, can cause allergic and inflammatory symptoms when activated by histamine secreted by Mast cells or basophils.

2024年7月10日 · Our results suggest that H1R in MS cholinergic neurons is critical for contextual fear retrieval, and could be a potential therapeutic target for individuals with fear-related disorders.

Histamine H1 type receptor (H1R) is a major subtype of histamine membrane receptors family, which has displayed diverse biological functions in various tissues and cells. In the current study, we have identified a novel physiological function of H1R in regulating osteoblastic differentiation and mineralization of the MC3T3-E1 cells.

We analysed HR expression in human gastrointestinal tissue specimens by quantitative reverse transcription‐polymerase chain reaction and immunostaining. We found that H1R, H2R, and H4R mRNA were expressed throughout the gastrointestinal tract, while H3R mRNA was absent.

2015年12月1日 · The histamine (HA) receptor subtype 1 (H1R) and H4R are expressed on immune cells and contribute to an inflammatory reaction. Both receptor subtypes individually enhance the intracellular concentrations of calcium and regulate the accumulation of cAMP, increase MAPK activity, and regulate expression …

2011年6月22日 · Histamine H 1 receptor (H 1 R) antagonists are very effective drugs alleviating the symptoms of allergic reactions. Here we show the crystal structure of the H 1 R complex with doxepin, a...

2021年10月1日 · Histamine-activated histamine H 1 receptor (H1R) signaling regulates many gene expressions, mainly through the protein kinase C (PKC)/extracellular signal-regulated kinases (ERK) signaling. Involvement of other signaling, including NF-κB, Wnt, RUNX-2, and Rho A signaling was also demonstrated.

2021年2月18日 · Our results suggest that the H 1 R deficiency in BF cholinergic neurons is critical for sensorimotor gating deficit, social impairments and anhedonia-like behavior. This finding may help to...