NCI-H23 [H23] is an epithelial-like cell that was isolated from the lung of a Black, 51-year-old, male patient with adenocarcinoma. This cell line was deposited by AF Gazdar and JD Minna and can be used in toxicology and cancer research.

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细胞描述:人 非小细胞肺癌细胞NCI-H23[H23] 分离自51岁黑人男性肺癌患者治疗前的肺癌组织,携 带K-ras 12 突变,突 变位于p53 基因的246 密码子位置,(ATC -> ATG, isoleucine -> methionine)。 表 达C-myc, L-myc, v-src, v-abl, v-erb B, c-raf 1, Ha-ras, Ki-ras, N-ras RNAs。 物种: 黑人, 男性,51岁. Little CD, et al. Amplification and expression of the c-myc oncogene in human lung cancer cell lines. Nature 306: 194-196, 1983.

Monoclonal antibodies that demonstrate specificity for several types of human lung cancer. High levels of intracellular bombesin characterize human small-cell lung carcinoma. Heterogeneity in the radiation survival curves and biochemical properties of human lung cancer cell lines.

nci-h23细胞是一种人非小细胞肺癌细胞，具体为腺癌亚型。 NCI-H23细胞贴壁生长，形态呈上皮细胞样 基因表达涉及C-myc、L-myc、v-src、v-abl、v-erb B、c-raf 1、Ha-ras、Ki-ras和N-ras RNAs。

nci-h23细胞源于一位51岁患有非小细胞肺癌黑人男性患者的治疗前的肿瘤组织，表达 C-myc、L-myc、v-src、v-abl、v-erbB、c-raf 1、Ha-ras、Ki-ras、N-ras RNAs；NCI-H23细胞

人非小细胞肺癌细胞系（nci-h23）源于一位51岁患有非小细胞肺癌黑人男性患者的治疗前的肿瘤组 织，表达C-myc、L-myc、v-src、v-abl、v-erbB、c-raf1、Ha-ras、Ki-ras、N-rasRNAs；NCI-H23细

NCI-H23 exhibits a high degree of c-myc DNA amplification (20-fold) but no detectable amplification of c-myc RNA. The cells stain positive for keratins 5+8 and 18 and vimentin but are negative for neurofilament. NCI-H23 cells are L-dopa decarboxylase-negative. They have a reported colony forming efficiency of 9.7% in soft agarose.

nci-h23，人非小细胞肺癌细胞，该细胞系是从一名51岁黑人男性肺腺癌患者接受治疗前取得的肺肿瘤组织中建立的。 后经检测发现：该细胞携带K-ras 12突变，p53基因246位密码子突变ATC突变为ATG，从而异亮氨酸突变为蛋…

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