Study objective: Because it has been hypothesized that histamine2 receptor antagonists (H2 RAs) might interfere with the action of proton pump inhibitors (PPIs) when the drugs are given concomitantly, we sought to compare the pharmacodynamic effects of simultaneous administration of a PPI and an H2 RA with the effects of each drug administered ...

The relationship between proton-pump inhibitor (PPI) use and chronic kidney disease (CKD) progression remains controversial. Specifically, there is a lack of data evaluating renal outcomes in established CKD patients. The aim of our study is to ...

氫離子幫浦抑制劑（PPI）的作用是不可逆地抑制 胃壁細胞 上的 氫 / 鉀 三磷酸腺苷 酵素 系統（又稱 氫/鉀離子ATP酶 （英语：H+/K+ ATPase））。 該系統是負責將氫離子分泌入胃內腔的氫離子幫浦，因此是醫藥界抑制胃酸分泌的理想目標。

2021年10月19日 · Histamine-2 receptor blockers (H2 blockers) and proton pump inhibitors (PPIs) are two treatment options for heartburn and acid reflux. These two classes of drugs both help …

Proton pump inhibitors (PPIs) and histamine type 2 receptor blockers (H2Bs) are used for stress ulcer prophylaxis. Although the PPIs have greater potency for acid suppression, their relative effectiveness for preventing clinically important GI bleeding (CIGIB) has not been established.

Proton pump inhibitors (PPIs), followed by histamine 2 receptor antagonists (H2RAs), are the most commonly used drugs to prevent gastrointestinal bleeding in critically ill patients through stress ulcer prophylaxis. The relative efficacy and drug-related adverse events of PPIs and H2RAs remain unclear.

PPI use, older age, and eGFR ≥ 90 mL/min/1.73 m 2 exhibited high hazard ratios. Conclusions: PPI use was significantly associated with an increased risk of chronic kidney disease …

2022年4月4日 · Keywords: Aciphex; Dexilant; Duexis; GERD; H2 receptor antagonists; Nexium; Pepcid; Prevacid; Prilosec; Protonix; Tagamet; Vimovo; Zantac; Zegerid; adverse effects ...

2009年12月31日 · H2 blockers reduce acid production, whereas PPIs block acid production altogether. So, PPIs are considered much stronger. Many H2 blockers are available, and most are over the counter (OTC) and do not require a doctor’s prescription. They come in generic or plain forms that are cheaper than the proprietary or marketed forms of the same drug.

2023年11月27日 · H2 blockers are often effective for individuals with mild to moderate symptoms, providing adequate relief in many cases. However, for individuals with more severe or …