Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each …

2024年12月25日 · H2AZ2 (H2A.Z Variant Histone 2) is a Protein Coding gene. Diseases associated with H2AZ2 include Lymph Node Carcinoma and Floating-Harbor Syndrome. Among its related pathways are RNA Polymerase I Promoter Opening and Packaging Of Telomere Ends. An important paralog of this gene is H2AZ1.

2021年2月24日 · Three histone H2A.Z variants have been identified. Two are transcribed by the non-allelic genes H2AFZ and H2AFV (called H2A.Z.1 and H2A.Z.2, respectively); and H2A.Z.2.2 is the result of...

Gene/transcipt that contains an open reading frame (ORF). Protein coding. A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt.

2020年5月18日 · The two H2A.Z isoforms played vital roles in cell proliferation. It is also predicted that unique functions of H2AFV contain spindle midzone and microtubule, while H2AFZ is especially associated with RNA export and spliceosome. Further, devoid H2AFZ may restrain liver cancer cell proliferation and cause many alternative splicing events.

[H2AFV] Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4).

2024年2月26日 · H2AFV是组蛋白H2A家族成员之一，通过与DNA相互作用，调控基因表达和细胞分化。 在细胞核内，H2AFV与其他组蛋白一起组成染色体，维持染色体的结构和稳定性。 同时，H2AFV还参与修饰染色体结构，影响基因的转录和表达，对细胞功能起着至关重要的作用。 目录号 PA1000-7841. H2AFV蛋白的基本信息包括：分子量为约14.5kDa，由约130个氨基酸组成。 H2AFV的序列结构与其他组蛋白H2A家族成员相似，包含核心结构域和保守的组蛋白折叠结构 …

H2AFV has 6,168 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or …

H2AFV的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为组蛋白是负责在真核生物染色体纤维的核小体结构基本核蛋白质。 核小体是由约146 bp的DNA围绕组蛋白包裹着的八聚体由多对四个核心组蛋白（H2A，H2B，H3和H4）的组成。 染色质纤维是通过接头组蛋白，H1的相互作用进一步压实，用核小体之间的DNA，以形成更高阶的染色质结构。 这个基因编码组蛋白H2A家族的一个成员。 编码不同同种型的几个转录变体，已经确定了该基因。 [ …

The present study evaluated the expression of lnc-H2AFV-1 in HNSCC tissues using quantitative real-time PCR (qPCR) and associated abundant lnc-H2AFV-1 expression with tumor size. Functionally, lnc-H2AFV-1 significantly promoted the proliferation of HNSCC cells in …