H2A histone family member X (usually abbreviated as H2AX) is a type of histone protein from the H2A family encoded by the H2AFX gene. An important phosphorylated form is γH2AX (S139), which forms when double-strand breaks appear.

2024年12月25日 · H2AX (H2A.X Variant Histone) is a Protein Coding gene. Diseases associated with H2AX include Nijmegen Breakage Syndrome and Large B-Cell Lymphoma. Among its related pathways are RNA Polymerase I Promoter Opening and Packaging Of Telomere Ends. An important paralog of this gene is H2AC6.

H2AFX, the gene coding for the H2A variant H2A.X, is a special case among histone variant genes (Fig. 2 A). It codes for an intronless 3′-poly-A as well as for a 3′-stem loop structure following a histone downstream element (HDE) containing mRNA (SL mRNA), a feature typical for RD histones [59–61] .

h2a组蛋白家族成员x （通常缩写为h2ax ）是h2afx基因编码的h2a家族的一种组蛋白。 重要的磷酸化形式是γH2AX（S139），当出现双链断裂时形成。 华文百科

Know comprehensive H2AFX protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction.

2024年6月1日 · H2AX is a well-known chromatin modification event in DNA damage response and human malignancies. H2AX phosphorylation (γ-H2AX) is necessary for DNA repair protein assembly at damaged chromatin regions. Detecting double strand breaks with phosphorylated histone H2AX may help in cancer treatment.

2021年2月16日 · Here we focus on the histone variant H2AFX (commonly known as H2AX, further referred to as H2A.X), which represents about 2–25% of the cellular H2A pool in mammals 5.

Increased H2AFX expression is associated with colorectal tumor progression. The SWI/SNF chromatin remodelling complex, earlier known to facilitate the phosphorylation of histone H2AX at Ser-139 (S139ph) after DNA damage, binds to gamma-H2AX (the phosphorylated form of H2AX)-containing nucleosomes in S139ph-dependent manner.

H2AFX的详细信息，包括基因名称，代码，染色体位置，相互作用关系和通路，简述为组蛋白是负责在真核生物染色体纤维的核小体结构基本核蛋白质。 每四个核心组蛋白中的两个分子（H2A，H2B，H3和H4）形成八聚体，其周围约146的DNA的碱基被包裹在重复单元，称为核小体。 接头组蛋白，H1与染色质成高阶结构的压实核小体和功能之间的接头DNA相互作用。 这个基因编码组蛋白H2A家族的成员，并且通过使用保守的茎 - 环终止基序产生两个转录和聚腺苷酸加 …

H2AFX is variant histone of the H2A family (review by Talbert and Henikoff, 2010). For additional background information on histones, histone gene clusters, and the H2A histone family, see HIST1H2AA (613499).