2019年6月26日 · Here we reveal that putative enhancers marked with H3 lysine 79 (H3K79) di or trimethylation (me2/3) (which we name H3K79me2/3 enhancer elements or KEEs) can be found in multiple cell types....

由dot1l实现的组蛋白h3k79甲基化标记，位于与活性基因表达相关的组蛋白的球状结构域。dot1l也是唯一一种催化赖氨酸甲基化的酶，它与具有set结构域甲基转移酶不同，而h3k79的去甲基化酶至今尚未被鉴定出来。

2019年4月1日 · Taken together, methylation of H3K79 by DOT1L promotes genomic stability at many levels by participating in the regulation of replication timing, DNA damage signaling and transcription recovery following DNA repair, regulation of TLS polymerases and perhaps by enhancing the rate of transcription elongation to reduce the likelihood of physical ...

2023年2月25日 · 通过染色质免疫沉淀结合高通量测序技术（ChIP-Seq），作者发现menin与H3K79甲基化标记在大量基因上存在共定位，而进一步的生物信息学分析显示，menin可能富集于被H3K79甲基化标记的基因增强子上，参与了基因转录的调控。

2022年4月22日 · 近日，湘雅二医院血液内科易彦教授、耳鼻咽喉科葛圣雷副教授在血液学和肿瘤学顶级期刊 《Journal of Hematology & Oncology》（中科院、JCR一区，IF：17.388）上发表了题为“Targeting the histone H3 lysine 79 methyltransferase DOT1L in MLL-rearranged leukemias“的肿瘤靶向治疗文章。 湘雅二医院为唯一第一作者、通讯作者单位。 肿瘤常规治疗主要包括手术、化疗和放疗，近些年来， 靶向药物的发展为肿瘤治疗开辟了新领域，它毒副作用 …

2021年1月22日 · H3K79 methylation by Dot1 is allosterically stimulated by H4K16 acetylation and by H2BK123 ubiquitination. Cross-talk between different histone posttranslational modifications can orchestrate distinct chromatin states to regulate transcription and gene silencing.

2023年2月16日 · We developed a nucleosome-based photoaffinity probe to capture proteins that recognize H3K79 dimethylation (H3K79me2) in a nucleosomal context. In combination with a quantitative proteomics approach, this probe identified menin as a H3K79me2 reader.

Yeast Dot1 and the mammalian homologue DOT1L are methyltransferases that can add up to three methyl groups to histone H3 lysine 79 (H3K79). H3K79 methylation is implicated in several processes, including transcription elongation by RNA polymerase II, the DNA damage response and cell cycle checkpoint activation.

2023年8月29日 · Disruptor of telomeric silencing 1 like (DOT1L) is the only known histone methyltransferase that methylates lysine 79 of histone H3 (H3K79), which is located on the surface of the nucleosome core, not the tail region. 21 It is accepted that H3K79 methylation is mainly associated with active transcription and transcription elongation. 22, 23 ...

2023年2月17日 · We developed a nucleosome-based photoaffinity probe to capture proteins that recognize H3K79 dimethylation (H3K79me2) in a nucleosomal context. In combination with a quantitative proteomics approach, this probe identified menin as a H3K79me2 reader.