H3K36me - Wikipedia
H3K36me is an epigenetic modification to the DNA packaging protein Histone H3, specifically, the mono-methylation at the 36th lysine residue of the histone H3 protein. There are diverse …
Structural and functional specificity of H3K36 methylation
2022年5月18日 · The methylation of histone H3 at lysine 36 (H3K36me) is essential for maintaining genomic stability. Indeed, this methylation mark is essential for proper …
Nature专家点评丨路超团队等揭示H3K36甲基化修饰与DNA甲基化 …
本研究揭示DNMT3A优先选择H3K36二甲基化区域，促进基因间区的DNA甲基化，并且Sotos综合征病人的血样和NSD1突变肿瘤中都出现了基因间区DNA甲基化的选择性丢失。 这一工作 …
Unique and Shared Roles for Histone H3K36 Methylation States in ...
2020年6月9日 · H3K36me limits co-transcriptional histone acetylation in two main ways: by recruitment and activation of the Rpd3S deacetylation complex that removes H3 and H4 N …
PNAS | 路超团队等揭示组蛋白H3K36M突变促癌机制中的关键因素
在最新研究中，路超团队及合作者首先在小鼠细胞系中构建了H3K36M突变株、H3K36me2甲基转移酶 Nsd1 /2双敲除株以及H3K36me3甲基转移酶 Setd2 敲除株。 研究通过 ChIP-seq 发 …
The histone mark H3K36me2 recruits DNMT3A and shapes the ... - Nature
2019年9月4日 · Here we report that NSD1-mediated H3K36me2 is required for the recruitment of DNMT3A and maintenance of DNA methylation at intergenic regions. Genome-wide analysis …
H3K36 Methylation in Neural Development and Associated Diseases
2020年1月8日 · Post-translational methylation of H3 lysine 36 (H3K36) is an important epigenetic marker that majorly contributes to the functionality of the chromatin. This mark is interpreted by …
H3K36 methylation maintains cell identity by regulating opposing ...
2023年7月17日 · At a cellular level, H3K36M facilitates epithelial plasticity by rendering fibroblasts insensitive to TGFβ signals. At a molecular level, H3K36M enables the decommissioning of …
Histone H3K36me2 and H3K36me3 form a chromatin platform
2022年8月3日 · Histone H3K36me3 mediates the high levels of methylation in the transcribed regions; however, it is unknown which histone mark guides the methylation in the other …
The histone mark H3K36me2 recruits DNMT3A and shapes the
Here we report that NSD1-mediated H3K36me2 is required for the recruitment of DNMT3A and maintenance of DNA methylation at intergenic regions. Genome-wide analysis shows that the …