H3K36me is an epigenetic modification to the DNA packaging protein Histone H3, specifically, the mono-methylation at the 36th lysine residue of the histone H3 protein. There are diverse modifications at H3K36, such as phosphorylation, methylation, acetylation, and ubiquitylation, which have many important biological processes. [ 1 ]

2022年5月18日 · The methylation of histone H3 at lysine 36 (H3K36me) is essential for maintaining genomic stability. Indeed, this methylation mark is essential for proper transcription, recombination, and DNA damage response. Loss- and gain-of-function mutations in H3K36 methyltransferases are closely linked to human developmental disorders and various cancers.

本研究揭示DNMT3A优先选择H3K36二甲基化区域，促进基因间区的DNA甲基化，并且Sotos综合征病人的血样和NSD1突变肿瘤中都出现了基因间区DNA甲基化的选择性丢失。 这一工作对H3K36甲基化修饰和DNA甲基化修饰间的调控作用做出了新的拓展，并且这一机制在疾病发生过程中有着潜在的生物学意义。 原文链接：doi.org/10.1038/s41586- 制版人：珂.

2020年6月9日 · H3K36me limits co-transcriptional histone acetylation in two main ways: by recruitment and activation of the Rpd3S deacetylation complex that removes H3 and H4 N-terminal tail acetylation (e.g., H3K27ac); and by the ability of H3K36me to repel the histone exchange factor Asf1, which helps deposit the histone exchange-associated mark H3K56ac ...

在最新研究中，路超团队及合作者首先在小鼠细胞系中构建了H3K36M突变株、H3K36me2甲基转移酶 Nsd1 /2双敲除株以及H3K36me3甲基转移酶 Setd2 敲除株。 研究通过 ChIP-seq 发现H3K36M突变对基因组范围内H3K36me2和H3K36me3修饰的影响有显著差异：H3K36M突变会导致H3K36me2修饰在整体水平上大幅降低，而对H3K36me3修饰水平的影响较小。

2019年9月4日 · Here we report that NSD1-mediated H3K36me2 is required for the recruitment of DNMT3A and maintenance of DNA methylation at intergenic regions. Genome-wide analysis shows that the binding and...

2020年1月8日 · Post-translational methylation of H3 lysine 36 (H3K36) is an important epigenetic marker that majorly contributes to the functionality of the chromatin. This mark is interpreted by the cell in several crucial biological processes including gene transcription and DNA methylation.

2023年7月17日 · At a cellular level, H3K36M facilitates epithelial plasticity by rendering fibroblasts insensitive to TGFβ signals. At a molecular level, H3K36M enables the decommissioning of mesenchymal enhancers...

2022年8月3日 · Histone H3K36me3 mediates the high levels of methylation in the transcribed regions; however, it is unknown which histone mark guides the methylation in the other regions. Here, we show that, in...

Here we report that NSD1-mediated H3K36me2 is required for the recruitment of DNMT3A and maintenance of DNA methylation at intergenic regions. Genome-wide analysis shows that the binding and activity of DNMT3A colocalize with H3K36me2 at non-coding regions of euchromatin.