H4K20me is an epigenetic modification to the DNA packaging protein Histone H4. It is a mark that indicates the methylation at the 20th lysine residue of the histone H4 protein. This mark can be mono-, di-, or tri-methylated. It is critical for genome integrity including DNA damage repair, DNA replication and chromatin compaction.

2021年8月20日 · Here, we describe a divergent role for histone H4 lysine 20 mono-methylation (H4K20me1) and demonstrate that it directly facilitates chromatin openness and accessibility by disrupting chromatin...

2016年3月1日 · We review the signaling pathways and functions associated with a single residue, H4K20, as a model chromatin and clinically important mark that regulates biological processes ranging from the DNA damage response and DNA replication to gene expression and silencing. The human genome consists of greater than 20,000 protein-coding genes (1).

2022年7月30日 · H4K20me是DNA包装蛋白组蛋白H4的一种表观遗传修饰。 它是一个表示在组蛋白H4蛋白的第20个赖氨酸残基上的单甲基化的标记。 这个标记可以被二甲基化和三甲基化。

2018年9月12日 · Our data suggest that a histone H4K20me-dependent chromatin compaction threshold imposes constraints and hence regulates the chromatin loading of ORC and the MCM2-7 complexes.

Here we discuss the regulation and function of H4K20 methylation (H4K20me) in the DNA damage response: we describe the writers, erasers, and readers of this important chromatin mark, and discuss combinatorial histone posttranslational modifications …

2022年2月7日 · In this review, we summarize the critical roles of histone lysine methylation, especially H4K20 methylation, and the relevant modulating enzymes in the DDR. Histone methylation has been recognized as being a PTM since 1964 (Murray, 1964).

2013年3月1日 · Intense research during the past few years has revealed histone H4 lysine 20 methylation (H4K20me) as critically important for the biological processes that ensure genome integrity, such as DNA damage repair, DNA replication and chromatin compaction.

2023年12月5日 · Histone H4 lysine 20 methylation (H4K20me) is a crucial modification for genome maintenance involved in replication, DNA damage repair, and chromatin...

2009年2月27日 · Methylation of histone H4 lysine 20 (H4K20me) is essential for recruiting checkpoint proteins 53BP1/Crb2 to DNA lesions and subsequent activation of a DNA-damage checkpoint. In fission yeast, Set9 (spKMT5) catalyzes mono-, di-, and trimethylation of H4K20. However, the mechanisms that regulate Set9 function are poorly understood.