ER stress signaling by regulated splicing: IRE1/HAC1/XBP1
2005年4月1日 · In the following report, we describe a variety of methods used to arrive at our current understanding of yeast IRE1-dependent HAC1 splicing and mammalian IRE1α …
Ire1 Has Distinct Catalytic Mechanisms for XBP1/HAC1 ... - Cell Press
2014年11月6日 · IRE1, an endoplasmic reticulum (ER) kinase/RNase, splices XBP1/HAC1 to produce an active transcription factor but also cleaves ER-associated mRNA through …
Ire1 Has Distinct Catalytic Mechanisms for XBP1/HAC1
2014年11月6日 · Using in vitro experiments, we found that IRE1 has two different modes of action: XBP1/HAC1 is cleaved by IRE1 subunits acting cooperatively within IRE1 oligomers, …
Crucial roles of Grr1 in splicing and translation of HAC1 mRNA …
2025年3月4日 · In the UPR signaling pathway, HAC1 mRNA in budding yeast 32,33,34 or XBP1 mRNA in metazoans 32,33,34 is targeted to the ER-resident protein kinase and endonuclease …
The protein kinase Ire1 has a Hac1-independent essential role in …
2022年2月2日 · Our finding that a constitutively active Hac1 bypasses the defects of ire1Δ mutants suggests that the relevant Ire1 target proteins are among those that are upregulated …
Endoplasmic stress sensor Ire1 is involved in cytosolic/nuclear …
In the present study, we therefore explored the HAC1-dependent and HAC1-independent physiological roles of Ire1 in P. pastoris cells. Our findings cumulatively indicate that in P. …
IRE1- and HAC1-independent transcriptional regulation in the …
Ire1p regulates synthesis of the basic leucine-zipper (bZIP)-containing transcription factor Hac1p by controlling splicing of HAC1 mRNA. Only spliced HAC1 mRNA (HAC1i) is translated, and …
Divergence and Conservation of the Major UPR Branch IRE1- bZIP …
2016年6月3日 · The inositol requiring enzyme 1 (IRE1) signaling pathway activated by the IRE1-mediated unconventional splicing of HAC1 in yeast, bZIP60 in plants and XBP1 in metazoans, …
ER stress signaling by regulated splicing: IRE1/HAC1/XBP1
Here, we summarize various approaches to study the IRE1-Hac1 pathway in yeast and the homologous IRE1-XBP1 pathway in mammalian cells. We present microbiological growth …
Regulation of the unfolded protein response in yeast by oxidative ...
In the unfolded protein response (UPR), Ire1 activates Hac1 to coordinate the transcription of hundreds of genes to mitigate ER stress. Recent work in Caenorhabditis elegans suggests …