Human neural stem cells genetically modified for brain repair in neurological disorders. Stable expression of neurogenin 1 induces LGR5, a novel stem cell marker, in an immortalized …

2018年9月14日 · In the present study, human neural stem cells (hNSCs) with tumor-tropic behavior were used as drug delivery vehicle to selectively target melanoma. A hNSC line …

2012年5月4日 · Here, we report the characterization of an FDA approved NSC, HB1.F3-CD, as a cell carrier for CRAd-S-pk7, a glioma-tropic oncolytic adenovirus. We show that NSCs …

Cell type: Neural stem cell; CL= CL_0000047. L-MYC expression maintains self-renewal and prolongs multipotency of primary human neural stem cells.

2007年5月1日 · NSCs can circumvent blood–brain barrier and migrate to the specific pathologic areas of brain with trophism. We introduced HB1.F3 immortalized human NSCs intravenously …

2006年9月15日 · As proof-of-concept, we used HB1.F3 cells engineered to secrete the prodrug activating enzyme cytosine deaminase. We investigated the potential of human NSCs to …

Here, we report the characterization of an FDA approved NSC, HB1.F3-CD, as a cell carrier for CRAd-S-pk7, a glioma-tropic oncolytic adenovirus. We show that NSCs replicate and release …

In this study, we employed human neural stem cells (HB1.F3; hNSCs) transduced with genes expressing Escherichia coli cytosine deaminase (HB1.F3.CD) and human interferon-beta …

HB1.F3.CD neural stem cells (NSCs) transduced with adenoviral vectors encoding rCE or hCE1m6 produce functional enzymes, retain tumor tropism, and enhance killing of glioma …

2016年1月15日 · A human neural stem cell line, HB1.F3, demonstrated neuroprotective properties in cerebral ischemia animal models. In this study, we have investigated about the mechanisms …