2024年12月25日 · HBA1 (Hemoglobin Subunit Alpha 1) is a Protein Coding gene. Diseases associated with HBA1 include Hemoglobin H Disease and Heinz Body Anemias. Among its related pathways are Erythrocytes take up carbon dioxide and release oxygen and Cellular responses to stimuli.

2025年3月8日 · Gene target information for HBA1 - hemoglobin subunit alpha 1 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

The HBA1 gene provides instructions for making a protein called alpha-globin. This protein is also produced from a nearly identical gene called HBA2. These two alpha-globin genes are located …

Hemoglobin subunit alpha, Hemoglobin, alpha 1, [5] is a hemoglobin protein that in humans is encoded by the HBA1 gene. [6] The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'.

HBA1 is a clinically useful parameter for identifying the risk for mortality, both for cardiovascular and non-cardiovascular mortality in diabetic hemodialysis patients. HBA1 level may be a predict aggressive tumor profile of prostate cancer in patients with diabetes mellitus.

The HBA1 gene, located on chromosome 16, is a genetic blueprint that holds the instructions for creating a protein called alpha-globin. Alpha-globin is a crucial component of hemoglobin, the complex protein molecule within red blood cells that carries oxygen from the lungs to tissues throughout the body.

HGNC Approved Gene Symbol: HBA1. Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38) : 16:176,680-177,522 (from NCBI) The alpha and beta loci determine the structure of the 2 types of polypeptide chains in the tetrameric adult hemoglobin, Hb A, alpha-2/beta-2.

2024年8月17日 · The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical.

This gene has 4 transcripts (splice variants), 9 paralogues and is associated with 9 phenotypes.

2024年8月16日 · TISSUE SPECIFICITY: Red blood cells. PTM: The initiator Met is not cleaved in variant Thionville and is acetylated. DISEASE: Defects in HBA1 may be a cause of Heinz body anemias (HEIBAN) [MIM:140700]. This is a form of non-spherocytic hemolytic anemia of …