Structure of the bile acid transporter and HBV receptor NTCP
2022年5月17日 · Our preS1 domain interaction analysis enables a mechanistic interpretation of naturally occurring HBV-insusceptible mutations in human NTCP. Together, our findings …
Regulation of the HBV Entry Receptor NTCP and its Potential in ...
NTCP mediates the specific binding of HBV to the host cell surface with high affinity by interacting with the preS1 region of the large surface protein (LHB) of HBV. NTCP confers HBV …
Structural insights into the HBV receptor and bile acid transporter NTCP
2022年5月17日 · Cryo-electron structures of the hepatitis B virus receptor NTCP show a distinct membrane topology compared with other SLC10 proteins, but a common bile acid transport …
NTCP转运体在药物研发中的应用简介 - 知乎 - 知乎专栏
NTCP是乙肝病毒和丁肝病毒的共同受体，介导病毒入侵肝细胞；其对胆汁酸（盐）在体内的调控发挥着重要的作用，主要转运胆盐和硫酸化化合物，同时也能够介导其它底物的转运，例如甲 …
乙型肝炎病毒体外感染和复制的细胞模型
2019年12月2日 · 近期有研究发现，外源表达hntcp的鼠肝细胞系aml12能一定程度地支持体外hbv感染，该细胞来源于过表达人转化生长因子α(htgfα)的转基因小鼠 [41-42] ，进一步研 …
Structural basis of hepatitis B virus receptor binding
2024年1月17日 · Myristoylated preS1 domain of the HBV large surface protein binds to the host receptor sodium-taurocholate cotransporting polypeptide (NTCP), a hepatocellular bile acid …
Role of sodium taurocholate cotransporting polypeptide (NTCP) in HBV …
2024年1月1日 · In this systematic review, our primary focus dwells on the structure and regulation of NTCP, as well as the mechanism involved in HBV internalization. We underscore recent …
Regulation of the HBV Entry Receptor NTCP and its Potential in ...
2022年4月12日 · Sodium taurocholate co-transporting polypeptide (NTCP), a transmembrane protein highly expressed in human hepatocytes and a mediator of bile acid transport, has been …
The Culprit Behind HBV-Infected Hepatocytes: NTCP - PubMed
2024年10月28日 · NTCP has been identified as the receptor that HBV and its satellite virus, hepatitis delta virus (HDV), use to enter hepatocytes. HBV entry into hepatocytes is tightly …
Molecular regulation of the hepatic bile acid uptake transporter and ...
2021年8月1日 · HBV/HDV entry requires NTCP and can be inhibited by a pre-S1 mimicking peptide. Inhibition of NTCP could be beneficial in metabolic disorders. Transporters expressed …