2018年1月25日 · In more aggressive HER2-amplified HCC-1954 cells, HCC-379 and HCC-NTC tumor growth rate in vivo was similar, but increased tumor necrosis was observed in HCC-379 tumors. In response to...

2025年1月30日 · SGK1 expression in metastases predict response to immune checkpoint inhibitors. Immune evasion by tumor cells is a principal obstacle to effectively targeting metastasis in hepatocellular carcinoma (HCC). However, the specific molecular mechanisms facilitating immune escape during metastatic seeding are not fully elucidated.

2023年11月29日 · Our recent study identified CD133/Prom1 in hepatocellular carcinoma (HCC) tumors to mark proliferative tumor-propagating cells with cancer stem cell-like properties, that follow a...

A significant reduction in the rate of tumor formation and growth in vivo was observed in T47D breast cancer cells stably expressing miR-379. In more aggressive HER2-amplified HCC-1954 cells, HCC-379 and HCC-NTC tumor growth rate in vivo was similar, but increased tumor necrosis was observed in HCC-379 tumors.

2025年3月9日 · 肝细胞癌（hcc）是最常见的原发性肝癌，是全球第六大常见的癌症和第三大癌症相关死亡原因。许多患者确诊时已处于晚期，限制了根治性疗法的选择，导致预后不良，其特点是 5 年生存率低，手术后频繁复发。 肝细胞癌的固有异质性进一步复杂化了治疗策略。

2024年11月22日 · Here, we identified SZT2-AS1 as a novel lncRNA in HCC, which was induced by hypoxia in a HIF-1-dependent manner and promoted HCC growth, metastasis and angiogenesis both in vitro and in vivo....

Neutralising antibody (NA) to S100A10 was used to evaluate the significance of EV-S100A10. Functionally, S100A10 promoted HCC initiation, self-renewal, chemoresistance and metastasis in vitro and in vivo. Of significance, we found that S100A10 was secreted by HCC cells into EVs both in vitro and in the plasma of patients with HCC.

2017年7月1日 · HCC1954 breast cancer cells were transduced with lentivirus to express elevated miR-379 (HCC-379) or a control sequence (HCC-NTC). Cells were implanted into the mammary fat pad (MFP) of mice and tumor progression monitored.

Here, we demonstrate that nuclear-localized HKDC1 acts as a protein kinase to promote hepatocellular carcinoma (HCC) cell proliferation. Mechanistically, HKDC1 phosphorylates RB binding protein 5 (RBBP5) at Ser497, which is crucial for MLL1 complex assembly and subsequent histone H3 lysine 4 trimethylation (H3K4me3) modification.

2024年3月9日 · 进一步比较TCGA HCC样本 （n=361） 中HBsAg阳性组 （n=106） 和HBsAg阴性组 （n=245） 的拷贝数变异 （CNVs） ，以研究HBV诱导的CNVs在HBV+HCC中是否过度表达。 结果显示，HBsAg+样本的chr8q扩增和chr4q、chr16q和chr17p缺失频率显著更高 （p<0.02） ，这些属于HBV诱导的CNVs的最高级别。