2024年5月30日 · Both dilated and hypertrophic cardiomyopathy restrict the pumping of blood in the body. A key difference between these types of cardiomyopathy is whether the ventricle dilates or thickens.

2022年6月22日 · Compared with NF hearts, DCM and HCM hearts showed a statistically credible decrease in cardiomyocytes and increases in vascular smooth muscle cells (VSMCs) and activated fibroblasts.

2023年1月9日 · 扩张型心肌病（Dilated cardiomyopathy, DCM）和肥厚型心肌病（Hypertrophic cardiomyopathy, HCM）都是心衰的病因，二者至终末期均可发展为心衰，带来严重的公共健康负担。 本研究通过单细胞核测序数据，探索DCM和HCM的转录组多样性，发现其潜在的治疗靶点。 1. Expression profiles ofcardiomyopathies. 2. Changes in cell subpopulations. 3. Activated fibroblasts in DCM and HCM. 4. Validation of activated fibroblasts. 5. Cardiac fibrosis assay. 1.

2021年1月25日 · We show strong genetic correlations between LV traits and cardiomyopathies, with opposing effects in HCM and DCM. Two-sample Mendelian randomization supports a causal association linking...

肥厚型心肌病(hypertrophic cardiomyopathy，HCM)是一类最常见的单基因常染色体显性遗传性心肌病，也是青少年运动性猝死的最常见病因。 HCM以不明原因的心室对称性或非对称性肥厚为主要特征，组织病理学改变具有一…

The goal of SHaRe, a first-of-its-kind effort, is to advance the understanding of Hypertrophic Cardiomyopathy (HCM), Dilated Cardiomyopathy (DCM), and Arrhythmogenic Cardiomyopathy, three types of heritable heart disease affecting nearly 2.4 million adults and children globally.

In the present review, we focus on three cardiomyopathies: dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), and arrhythmogenic cardiomyopathy (ACM). Herein we aim to provide a concise but practical overview of their pathogenesis, clinical features, diagnostic work-up, management, and key aspects worthy of further investigation.

2021年5月5日 · The major cardiomyopathies, diseases of the myocardium, have clinically been classified as hypertrophic cardiomyopathy (HCM), dilated cardiomyopathy (DCM), and arrhythmogenic right ventricular cardiomyopathy (ARVC). 1 Each has been defined by ventricular structure and function and, in the case of ARVC, supplemented by arrhythmia data.

Dilated cardiomyopathy (DCM) is characterized by left ventricular dilatation and impaired systolic function and is a leading cause of heart failure. DCM is considered idiopathic if no other discernable cause such as ischemia, valvular disease or hypertension is present.

2014年10月5日 · 心肌间质和局灶性纤维化是hcm的标志，纤维化导致hcm患者舒张和收缩功能受损。目前hcm间质纤维化的确切分子机制尚不清楚，较为统一的假设是发育生物学假设。