Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 is a protein that in humans is encoded by the HCN4 gene. [5] [6] [7] [8] There are four HCN channels. HCN4 is …

2024年12月25日 · HCN4 (Hyperpolarization Activated Cyclic Nucleotide Gated Potassium Channel 4) is a Protein Coding gene. Diseases associated with HCN4 include Sick Sinus …

2025年3月1日 · Fig. 1: HCN4 antagonists or Hcn4 knock out prevent action potential rate increases by heat in SAN cells. Fig. 2: HCN4 current (I f) has a Q 10 of ~2.0 that is …

2025年2月8日 · A novel mutation is found in HCN4 gene causing symptoms of sinus bradycardia in unrelated male Moroccan Jews. These findings suggest HCN4 as a genetic susceptibility …

该基因的突变与病态窦房结综合征 2 有关，也称为房颤伴心动过缓或家族性窦性心动过缓。 已在 15 号染色体上鉴定出两个假基因。 [RefSeq 提供，2008 年 10 月] This gene encodes a …

2020年11月3日 · It is highly debated how cyclic adenosine monophosphate-dependent regulation (CDR) of the major pacemaker channel HCN4 in the sinoatrial node (SAN) is involved in heart …

2013年8月2日 · Results demonstrated that, at cardiac crescent stages, HCN4 marks the first heart field, with HCN4CreERT2 allowing assessment of cell fates adopted by first heart field …

The HCN4 gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated ion channel family, which are expressed at the cell membrane and contribute to the resting …

The HCN4 gene provides instructions for making a channel that transports positively charged atoms (ions) into heart muscle cells. This channel is located primarily in the sino-atrial (SA) …

hcn通道 共有4种：hcn1, hcn2, hcn3, 和hcn4。 自从HCN通道被发现后，它的超极化激活特性立即引起了科学研究者的重视。 HCN通道参与了许多神经活动,包括参与调节神经元活动的节律性 …