E1 is one of two subunits of the envelope glycoprotein [1] found in the hepatitis C virus. [2][3] The other subunit is E2. This protein is a type 1 transmembrane protein with a highly glycosylated …

2022年10月20日 · Hepatitis C virus (HCV) infection is a leading cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma in humans and afflicts more than 58 million people …

2024年9月4日 · Fifty-eight million individuals worldwide are affected by chronic hepatitis C virus (HCV) infection, a primary driver of liver cancer for which no vaccine is available 1. The HCV …

2023年3月18日 · Vaccination with a mRNA-LNP expressing soluble E1 (sE1) significantly reduced vv/HCV titer in the mouse ovary. However, the addition of sE2 mRNA-LNP for immunization …

The E1 protein plays a role in multiple steps in the HCV replication cycle, including attachment to the host cell, endosome-lipid membrane fusion, and assembly. The role for E1 in attachment …

2024年9月5日 · 这项工作解析了首个丙肝病毒hcv表面糖蛋白e1/e2的高阶复合物冷冻电镜结构。研究结果表明，体外纯化的hcv e1/e2形成了二聚体组装形式，而非其他包膜病毒常见的三聚体 …

hcv是一个由脂膜包裹的正链rna病毒。来源于宿主细胞膜的病毒包膜上整合有病毒编码的包膜蛋白e1和e2。被这层膜包裹的是结合有hcv核心蛋白的rna基因组。这个看似简单的病毒如今已是 …

2022年10月21日 · The HCV envelope E1 and E2 glycoproteins are essential for viral entry and comprise the primary antigenic target for neutralizing antibody responses. The molecular …

The two HCV envelope glycoproteins E1 and E2 are released from HCV polyprotein by signal peptidase cleavages. These glycoproteins are type I transmembrane proteins with a highly …

2022年11月8日 · HCV的基因组所编码的糖蛋白经蛋白酶加工后，可以最终形成3种结构蛋白和7种非结构蛋白，包膜糖蛋白E1和E2即属于结构蛋白，二者以异源二聚体的形式存在。 其中，E2 …