2003年10月24日 · Our experimental data showing that both MTA1 and MTA2 form distinct protein complexes with HDAC1 and HDAC2 support this hypothesis. Furthermore, our purification of the core MTA-HDAC complex proves that the association between MTA1 and HDACs is tight, and the whole MTA1 complex may build upon this core.

2024年9月1日 · HDAC complexes play vital roles in the regulation of key biological processes such as transcription, replication, and DNA repair. Moreover, deregulated HDAC complex function is implicated in human diseases including cancer. Therapeutic strategies targeting HDAC complexes are being sought actively.

2020年12月1日 · NuRD is built from a 2:2:4 (MTA, HDAC, and RBBP) deacetylase module and a 1:1:1 (MBD, GATAD2, and Chromodomain-Helicase-DNA-binding [CHD]) remodeling module, and the complex displays considerable structural dynamics. The enigmatic GATAD2 controls the asymmetry of the complex and directly recruits the CHD remodeler.

Class I histone deacetylases (HDAC1, HDAC2, and HDAC3) are recruited by cognate corepressor proteins into specific transcriptional repression complexes that target HDAC activity to chromatin...

2023年7月24日 · Here we unveil a genetic interaction between histone deacetylase 1 (HDAC1) and HDAC2, wherein each paralog is synthetically lethal with hemizygous deletion of the other.

The acetylated MTA1 allows its interaction with HDAC – presumably the acetylated substrate serves as a docking platform for HDAC – to form the MTA1-HDAC/NuRD complex to repress Gαi2-transcription.

2014年10月29日 · The class I histone deacetylase (HDAC) corepressor complexes are multi-protein assemblies that contain one or more enzymes that modify chromatin, components with nucleosome or DNA binding activity and proteins that function to …

2007年2月27日 · MTA-2 is an essential component of an enzymatically active recombinant HDAC1/HDAC2 protein complex, while in CoREST the SANT domain is necessary for recruiting HDAC1 activity.

Histone deacetylases (HDACs) catalyze the removal of acetyl groups from the ε-amino groups of lysine residues. The reversible acetylation of histones and non-histone proteins by histone acetyltransferases (HATs) and HDACs play critical roles in …

NuRD is built from a 2:2:4 (MTA, HDAC, and RBBP) deacetylase module and a 1:1:1 (MBD, GATAD2, and Chromodomain-Helicase-DNA-binding [CHD]) remodeling module, and the complex displays considerable structural dynamics. The enigmatic GATAD2 controls the asymmetry of the complex and directly recruits the CHD remodeler. The MTA-MBD interaction