2024年12月25日 · HDAC10 (Histone Deacetylase 10) is a Protein Coding gene. Diseases associated with HDAC10 include Neuroblastoma and Conjugate Gaze Palsy. Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and Gene expression (Transcription).

Histone deacetylase 10 is an enzyme that in humans is encoded by the HDAC10 gene. [5][6][7] HDAC10 is a class IIb HDAC. It specifically has selectivity for long, slender polyamines like N8-acetylspermidine. [8] Acetylation of histone core particles …

hdac8和hdac11则优先水解非乙酰酰基赖氨酸底物，hdac10则是一种多胺去乙酰化酶。 HDAC催化机制 乙酰赖氨酸底物位于一个由疏水残基围绕的狭窄通道中，其中酪氨酸残基通过构象翻转与羰基氧形成氢键（图A）。

2017年5月18日 · Here we report that histone deacetylase 10 (HDAC10) is a robust polyamine deacetylase, using recombinant enzymes from Homo sapiens (human) and Danio rerio (zebrafish).

2021年9月6日 · 西达本胺由微芯生物开发的亚型选择性HDAC抑制剂，针对HDAC第I类的1、2、3亚型和第IIb类的10亚型，属于表观遗传调控剂类药物，具有对肿瘤发生发展相关的表观遗传异常的重新调控作用。 它通过抑制这4种亚型以增加染色质组蛋白的乙酰化水平来引发染色质重塑，产生针对肿瘤发生的多条信号传递通路基因表达的改变（即表观遗传改变），直接抑制肿瘤细胞周期并诱导细胞凋亡；诱导和激活自然杀伤细胞（NK）和抗原特异性细胞毒T细胞（CTL）介导的 …

2023年10月1日 · HDAC10 possesses unique substrate selectivity. HDAC10 is the only polyamine deacetylase identified so far. Structural insights in HDAC10 led to efficient substrates and the first potent inhibitors. Polyamine deacetylase activity was discovered more than 40 years ago, but the responsible histone deacetylase 10 (HDAC10) was described only recently.

The cytosolic class IIb histone deacetylase HDAC10 is an emerging target for drug design. As an inducer of autophagy, its selective inhibition suppresses the autophagic response that otherwise attenuates the efficacy of cytotoxic cancer chemotherapy ...

2025年2月8日 · HDAC10 suppresses expression of matrix metalloproteinase (MMP) 2 and 9 genes, which are known to be critical for cancer cell invasion and metastasis; results demonstrate that HDAC10 protects cancer cells from cytotoxic agents by mediating autophagy and identify this HDAC isozyme as a druggable regulator of advanced-stage tumor cell survival

2018年7月3日 · Here, we show that depleting or inhibiting HDAC10 results in accumulation of lysosomes in chemotherapy-resistant neuroblastoma cell lines, as well as in the intracellular accumulation of the...

2022年12月23日 · HDAC10以脱乙酰酶不依赖的方式与未感染细胞的IRF3结合，通过TANK结合激酶1 (TANK-binding kinase 1，TBK1)抑制IRF3 Ser 396 位点的磷酸化。病毒感染后，HDAC10通过与LC3-II的相互作用靶向自噬介导降解。