Histone deacetylase 11 is a 39kDa histone deacetylase enzyme that in humans is encoded by the HDAC11 gene on chromosome 3 in humans and chromosome 6 in mice. [5] [6] It is the only Class IV HDAC since it is not highly homologous with either Rpd3 or hda1 yeast enzymes and so does not fit into either Class I or Class II. [7]

组蛋白去乙酰化酶11 (histone deacetylases 11, HDAC11) 是IV 类HDAC 的唯一成员，能够催化组蛋白和非 组蛋白赖氨酸残基去乙酰化并具有去脂酰化活性。 HDAC11 与免疫细胞的成熟、分化和功能密切相关，多

2024年12月25日 · HDAC11 (Histone Deacetylase 11) is a Protein Coding gene. Diseases associated with HDAC11 include Mature T-Cell And Nk-Cell Lymphoma and Peripheral T-Cell Lymphoma. Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and Gene expression (Transcription).

The histone deacetylases (HDACs) family of enzymes possess deacylase activity for histone and nonhistone proteins; HDAC11 is the latest discovered HDAC and the only member of class IV. Besides its shared HDAC family catalytical activity, recent studies underline HDAC11 as a multifaceted enzyme with …

hdac8和hdac11则优先水解非乙酰酰基赖氨酸底物，hdac10则是一种多胺去乙酰化酶。 HDAC催化机制 乙酰赖氨酸底物位于一个由疏水残基围绕的狭窄通道中，其中酪氨酸残基通过构象翻转与羰基氧形成氢键（图A）。

2022年3月12日 · This study provided evidence that HDAC11 is highly expressed in the aortic intima of HFD-fed ApoE −/− mice and HDAC11 knockdown significantly suppressed pyroptosis via inhibiting NLRP3/caspase...

2021年9月6日 · HDAC（histonedeacetylases），中文全称叫做组蛋白脱乙酰酶，是组蛋白修饰过程中一类重要的酶，催化并调控组蛋白去乙酰化。 目前在人体中已经发现18种HDAC，分别属于四种类别（I、II、III和IV）。 其中Ⅰ、Ⅱ和Ⅳ类等11个亚型均为Zn2+依赖型的蛋白；Ⅲ类亚族的7个亚型Sir1～7以NAD+为催化活性位点[1]。 Ⅰ类HDAC包括HDAC1、2、3和8，其与酵母RPD3蛋白同源，分布在细胞核内，主要发挥抑制基因转录的功能。 Ⅱ类HDAC（HDAC4、5、6、7、9 …

2022年10月20日 · In this review, we summarize the recent progress on the role and mechanism of HDAC11 in the regulation of metabolic disorders, with the focus on its regulation on adipogenesis, lipid metabolism, metabolic inflammation, glucose tolerance, immune responses and energy consumption.

2025年2月8日 · HDAC11 is a novel regulator of fatty acid oxidative metabolism in skeletal muscle. HDAC11 regulates expression of C/EBPbeta and immunosuppressive molecules in myeloid-derived suppressor cells. HDAC11 promotes meiotic apparatus assembly during mouse oocyte maturation via decreasing H4K16 and alpha-tubulin acetylation.

2023年9月3日 · Histone deacetylase 11 (HDAC11) is a unique member of the histone deacetylase family that plays an important role in the regulation of gene expression and protein function. In recent years, research on the role of HDAC11 in tumors has attracted increasing attention. This review summarizes the curren …