2022年1月31日 · Allografts of pancreatic cancer in mouse were applied to test the efficiency of HDAC5 inhibition and anti-PD1 co-treatment. Results: HDAC5 regulated PD-L1 expression by directly interacting with NF-κB p65; this interaction was suppressed by p65 phosphorylation at serine-311. Additionally, HDAC5 diminished p65 acetylation at lysine-310, which ...

2018年7月16日 · HDAC5 inhibition increases acetylated p65 levels in the nucleus, which is important for CXCR4 transcription. Inhibition of nuclear factor-κB (NF-κB) signaling suppresses HDAC5-mediated CXCR4 upregulation, enhanced HSC homing, and engraftment.

Results: HDAC5 regulated PD-L1 expression by directly interacting with NF-κB p65; this interaction was suppressed by p65 phosphorylation at serine-311. Additionally, HDAC5 diminished p65 acetylation at lysine-310, which is essential for the transcriptional activity of p65.

HDAC5 is considered as a reliable therapeutic target for anticancer drugs. In light of recent findings regarding the role of epigenetic reprogramming in tumorigenesis, in this review, we provide an overview of the expression, biological functions, regulatory mechanisms, and clinical significance of HDAC5 in cancer.

HDAC5 modulates PD-L1 expression and cancer immunity via p65 deacetylation in pancreatic cancer. Rationale: Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a dismal 5-year survival less than 10%. Most patients with PDAC exhibit poor response to single-agent immunotherapy.

2018年7月16日 · In this work, we show that upon HDAC5 inhibition, acetylated p65 binds to the CXCR4 promotor region, transcriptionally upregulates CXCR4 surface expression and enhances homing and long-term ...

Results: HDAC5 regulated PD-L1 expression by directly interacting with NF-κB p65; this interaction was suppressed by p65 phosphorylation at serine-311. Additionally, HDAC5 diminished p65 acetylation at lysine-310, which is essential for the transcriptional activity of p65. Importantly, we demonstrated that HDAC5

2022年1月31日 · Results: HDAC5 regulated PD-L1 expression by directly interacting with NF-κB p65; this interaction was suppressed by p65 phosphorylation at serine-311. Additionally, HDAC5 diminished p65...

2024年5月31日 · In the realm of immune modulation, HDAC5 curtails the transcriptional activity of p65, thereby influencing PD-L1 expression and cancer immunity . Regarding apoptosis regulation, it has been reported that HDAC oversees the transcription of miR-15 and miR-16, subsequently impacting pancreatic stellate cell apoptosis [ 41 ].

2021年12月1日 · Here, we describe that HDAC5 regulates the phosphorylation of IKKβ and p65 by deacetylating and inactivating PP2A. HDAC5 promotes NF-κB activation in a deacetylation-dependent manner. HDAC5 deficiency suppresses the production of cytokines, such as TNF, both in vitro and in vivo.