2022年1月31日 · Allografts of pancreatic cancer in mouse were applied to test the efficiency of HDAC5 inhibition and anti-PD1 co-treatment. Results: HDAC5 regulated PD-L1 expression by …

2018年7月16日 · HDAC5 inhibition increases acetylated p65 levels in the nucleus, which is important for CXCR4 transcription. Inhibition of nuclear factor-κB (NF-κB) signaling …

Results: HDAC5 regulated PD-L1 expression by directly interacting with NF-κB p65; this interaction was suppressed by p65 phosphorylation at serine-311. Additionally, HDAC5 …

HDAC5 is considered as a reliable therapeutic target for anticancer drugs. In light of recent findings regarding the role of epigenetic reprogramming in tumorigenesis, in this review, we …

HDAC5 modulates PD-L1 expression and cancer immunity via p65 deacetylation in pancreatic cancer. Rationale: Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a dismal …

2018年7月16日 · In this work, we show that upon HDAC5 inhibition, acetylated p65 binds to the CXCR4 promotor region, transcriptionally upregulates CXCR4 surface expression and …

Results: HDAC5 regulated PD-L1 expression by directly interacting with NF-κB p65; this interaction was suppressed by p65 phosphorylation at serine-311. Additionally, HDAC5 …

2022年1月31日 · Results: HDAC5 regulated PD-L1 expression by directly interacting with NF-κB p65; this interaction was suppressed by p65 phosphorylation at serine-311. Additionally, …

2024年5月31日 · In the realm of immune modulation, HDAC5 curtails the transcriptional activity of p65, thereby influencing PD-L1 expression and cancer immunity . Regarding apoptosis …

2021年12月1日 · Here, we describe that HDAC5 regulates the phosphorylation of IKKβ and p65 by deacetylating and inactivating PP2A. HDAC5 promotes NF-κB activation in a deacetylation …