Histone deacetylase 7 is an enzyme that in humans is encoded by the HDAC7 gene. [5][6][7] Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA.

hdac7 通过 ppp 代谢物 rl5p 发挥作用，优先响应近端危险信号. 确定了 hdac7 在 6pgd 激活、nadph 产生、ppp 通量和 ros 依赖性细菌杀灭中的作用后，作者回到了最初的观察结果，即 hdac7 限制巨噬细胞响应近端危险时产生 il-1β（图 1 b 和 d–f)。

2024年12月25日 · HDAC7 (Histone Deacetylase 7) is a Protein Coding gene. Diseases associated with HDAC7 include Hematologic Cancer and Cockayne Syndrome. Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain …

HDAC抑制剂具有灵活的结构，易于与其他抗肿瘤药物结合，例如拓扑异构酶（Top）抑制剂和受体酪氨酸激酶（RTK）抑制剂，包括血管内皮生长因子受体（VEGFR）、表皮生长因子受体（EGFR）、EZH2（Enhancer of Zeste Homolog 2）及c-Met抑制剂。 将HDAC抑制剂与这些抗肿瘤药物联合使用可对癌细胞的生命过程产生协同作用。 因此，双功能单分子（双靶点药物）成为癌症治疗中的一种极具前景的策略，同时也是解决单靶点药物毒性过高，耐受性等问题的合理方 …

2019年8月2日 · We found that HDAC1 and HDAC3 inhibition or knockdown results in HDAC7 downregulation, which is associated with a decrease in histone 3 lysine 27 acetylation (H3K27ac) at transcription start...

2025年1月30日 · HDAC7 has been identified as a potential therapeutic target for various diseases, including autoimmune diseases like Crohn's disease 910, solid tumors like non-small-cell lung cancer 11, 12, 13, 14, 15, and notably, hematologic malignancies like diffuse large B cell lymphoma (DLBCL) and acute myeloid leukemia (AML) 16, 17, 18.

2023年1月24日 · Here, we demonstrate that the cytoplasmic lysine deacetylase HDAC7 in macrophages is a metabolic switch that triages danger signals to enable the most appropriate immune response. Lipopolysaccharide (LPS) and soluble signals indicating distal or far-away danger trigger HDAC7-dependent glycolysis and proinflammatory IL-1β production.

2025年2月8日 · Histone deacetylase 7 (HDAC7) expression is increased in lung cancer samples and higher HDAC7 levels predict a poor outcome. HDAC7 promotes tumor growth and metastasis. Ectopic expression of HDAC7 suppresses mRNA and protein levels of plakoglobin in lung cancer cells, whereas silencing HDAC7 increases the the expression of plakoglobin.

This review focuses on the cell biology of HDAC7, including the regulation of its cellular localisation and molecular mechanisms of action, as well as its associative and causal links with cancer and inflammatory, metabolic and fibrotic diseases.

2022年3月18日 · 分子、细胞、体内和疾病关联研究表明，hdac7 通过多种机制发挥作用，控制免疫细胞、破骨细胞、肌肉、内皮和上皮的生物过程。 这种 HDAC 蛋白调节基因表达、细胞增殖、细胞分化和细胞存活，从而控制发育、血管生成、免疫功能、炎症和代谢。