Liver disease alters high-density lipoprotein composition, …
High-density lipoproteins (HDL) are important endogenous inhibitors of inflammatory responses. Functional impairment of HDL might contribute to the excess mortality experienced by patients …
Biochemistry, High Density Lipoprotein - StatPearls - NCBI Bookshelf
2022年9月26日 · HDL synthesis occurs in the liver and the intestines. The first step of HDL synthesis involves the production of its main structural apolipoproteins, Apo-AI. Apo-AI is the …
Enterically derived high-density lipoprotein restrains liver …
2021年7月23日 · All showed that intestinally derived HDL reduced liver injury. From a therapeutic perspective, oral delivery of LXR agonists proved effective in protecting the liver by …
High-density lipoprotein cholesterol as an indicator of liver …
Results: In the analysis group, albumin, bilirubin, INR, and Model for End-Stage Liver Disease (MELD) score correlated strongly with high-density lipoprotein (HDL) cholesterol, weakly but …
Regulation and deregulation of cholesterol homeostasis: The liver …
Dietary cholesterol is also transferred from the intestine to the liver by HDL; all HDL particles are internalized in the liver, interacting with the hepatic scavenger receptor (SR-B1). Once in the …
Enterically derived high-density lipoprotein restrains liver injury ...
2021年7月23日 · The biogenesis of high-density lipoprotein (HDL) requires apoA1 and the cholesterol transporter ABCA1. Although the liver generates most of the HDL in the blood, …
High-density lipoproteins and non-alcoholic fatty liver disease
2023年9月1日 · Non-alcoholic fatty liver disease (NAFLD) is associated with reduced HDL levels. The cholesterol efflux capacity of HDL particles is impaired in NAFLD patients. NAFLD is …
Lipid and Lipoprotein Metabolism in Liver Disease
2019年7月21日 · Alterations in hepatic lipid metabolism can contribute to the development of chronic liver disease, such as nonalcoholic fatty liver disease (NAFLD) and add to the …
High-Density Lipoprotein Function and Dysfunction in Health and …
The major structural protein component of HDL is apolipoprotein A-I (apoA-I), formed in both the liver (~80%) and intestine (~20%) and secreted in a lipid-free state. Efflux of phospholipids and …
Association between the NHHR and hepatic steatosis and liver
4 天之前 · Wang, K. et al. Non-HDL-cholesterol to HDL-cholesterol ratio is a better predictor of new-onset non-alcoholic fatty liver disease than non-HDL-cholesterol: A cohort study. Lipids …