Rtęć (Hg, łac. hydrargyrum, z gr. ὑδράργυρος hydrargyros ‘wodne srebro’) – pierwiastek chemiczny z grupy metali przejściowych. Uznana za pierwiastek przez Lavoisiera. Rtęć jest jedynym metalem występującym w warunkach normalnych w stanie ciekłym. Rtęć występuje w skorupie ziemskiej w ilości 0,05 ppm.

2025年1月15日 · Accelerated senescence of renal tubular epithelial cells (RTEC) is critical in the progression of diabetic kidney disease (DKD). GLIS family zinc finger 1 (Glis1) alleviates age-related renal fibrosis in naturally aged mice.

2018年1月24日 · Mitochondrial fission/mitophagy inhibitor Mdivi-1 significantly enhanced RTEC senescence under HG conditions, whereas autophagy/mitophagy agonist Torin1 inhibited cell senescence. MitoTempo inhibited HG-induced mitochondrial reactive oxygen species and cell senescence with or without Mdivi-1.

2018年1月24日 · Mitochondrial fission/mitophagy inhibitor Mdivi-1 significantly enhanced RTEC senescence under HG conditions, whereas autophagy/mitophagy agonist Torin1 inhibited cell senescence. MitoTempo...

2020年9月1日 · Decoy receptor 2 (DcR2) induces renal tubular epithelial cell (RTEC) senescence leading to fibrosis in high glucose (HG). (a,b) Expression of DcR2 and p16 mRNA was detected at different time points after HG (30 mmol/l) treatment (n = 6 for each group).

2022年4月1日 · Here, we investigated the role and mechanisms of tumor necrosis factor alpha-induced protein 8-like 1 (TNFAIP8L1/TIPE1) in high glucose (HG)-induced mitochondrial dysfunction in RTECs and DN progression. TIPE1 expression was predominantly upregulated in RTECs in patients with DN and mice with streptozotocin (STZ)-induced DN.

2022年9月21日 · In summary, the suppression of REDD1 decreases HG-induced apoptosis and EMT in RTEC, according to our findings in this trial. This study also highlights that REDD1 and TXNIP form a biological complex aided by HG. The mitochondrial route is used by the REDD1/TXNIP complex to drive oxidative stress-induced RTEC apoptosis and EMT.

2022年3月10日 · 在此，我们研究了肿瘤坏死因子α诱导蛋白8-like 1 （TNFAIP8L1/TIPE1）在高糖（HG）诱导的RTECs和DN进展中的线粒体功能障碍中的作用和机制。 本研究于2022年4月发表在《Redox Biology》IF:11.799期刊上。 为了初步评估TIPE1在DN中的潜在作用，作者首先分析了TIPE1在Nephroseq数据库DN患者中表达，结果显示，相比于健康组，TIPE1在DN组的表达显著升高 (Fig. 1A)，免疫组化进一步确认了该结果 (Fig. 1B)。 免疫荧光染色显示TIPE1表达主要 …

2020年10月12日 · Using a HG-induced HK-2 cell injury model, the present study demonstrated that miR-199a-3p attenuated HG-induced the apoptosis and release of pro-inflammatory factors in HK-2 cells. These results suggested that miR-199a-3p exerted its protective role against HG-induced RTEC injury via the suppression of apoptosis and the inflammatory response.

Upon persistent exposure to high-glucose (HG) ambiance, RTECs may sustain dysfunction or injury following activation of the signaling of cellular senescence, which in turn leads to tubular injury via a pro-inflammatory response known as senescence-associated secretory phenotype (SASP) …