The transcription factor GLI3 is a member of the Hedgehog (Hh/HH) signaling pathway that can exist as a full length (Gli3-FL/GLI3-FL) or repressor (Gli3-R/GLI3-R) form. In response to HH …

Activation of Hh/GLI in cancer is most often through a non-canonical method of activation, independent of ligand binding. This review is intended to summarize our current understanding …

III 型是 Gli 介导的 Hh 信号转导：(即不依赖 Smo、依赖 Gli 的 Hh 信号转导)，Gli 转录因子的激活独立于 Gli 的任何上游信号，如 Hh 配体、Ptch 和 Smo。 已经观察到多种信号级联，如 K …

2017年6月29日 · GLI3R inhibits Hh signaling and is required for response to SMO antagonist in AML. GLI3 is silenced in AML, and decitabine restores GLI3 expression and leads to …

2022年2月10日 · Contrary to current dogma, we find that GLI3 is inert prior to HH signaling. While GLI3 binds to most targets, loss of Gli3 does not increase target gene expression, enhancer …

2020年4月3日 · In response to HH activation, GLI3-FL regulates HH genes by targeting the GLI1 promoter. In the absence of HH signaling, GLI3 is phosphorylated leading to its partial …

2025年1月16日 · Our study unveiled a novel role of the truncated form of Gli (t-Gli3) in advancing CRPC. Investigation into Gli3 regulation revealed a Smo-independent mechanism for its …

2025年1月2日 · We identified chromatin remodelling complex Hira to interact with Gli3R protein, showed that its loss-of-function changes Hh pathway activity, and examined possible …

2024年12月25日 · GLI3 (GLI Family Zinc Finger 3) is a Protein Coding gene. Diseases associated with GLI3 include Greig Cephalopolysyndactyly Syndrome and Polydactyly, Postaxial, Type …

In summary, we have identified TLR signaling as a novel HH-independent signaling pathway that regulates GLI3 and demonstrate that this regulation is dependent on TRIF-IRF3 signaling axis. …