Hypoxia-inducible factor - Wikipedia
Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia. [1][2] They also respond to instances of …
摘 要：缺氧诱导因子-1(hif-1) 和缺氧诱导因子-2(hif-2) 是细胞应对缺氧时关键的转录因子，在生物体 生理及病理过程中有重要的作用。 HIF 由一个α亚基和一个β亚基组成二聚体。
HIF-1 and HIF-2 in cancer: structure, regulation, and therapeutic ...
2025年1月18日 · HIF-1 predominantly binds to genes regulating carbohydrate metabolism, while HIF-2 binds to genes that play an essential role in stem cell pluripotency by mediating the …
2019诺奖解读：缺氧诱导因子 (HIF)的发现及基于其通路的医学研究
HIF-2是由HIF-2α和HIF-2β相结合发挥作用，但是HIF-2α的相对少一点，它仅表达于血管内壁细胞以及部分的Ⅱ型肺细胞，所以它的作用不像HIF-1α那么重要。 缔造HIF领域研究基石--克 …
HIF-1 and HIF-2 transcription factors--similar but not identical
Hypoxia inducible factor (HIF)-1 and HIF-2 are heterodimeric transcription factors mediating the cellular response to hypoxia. Recent data indicate that not only ubiquitous HIF-1 alpha, but …
HIF-1 and HIF-2: working alone or together in hypoxia? - PMC
HIF is an α/β heterodimer that binds hypoxia response elements (HREs) at target gene loci under hypoxic conditions (Figure 1). In the presence of oxygen, HIF is inactivated by …
Recent progress in the development of hypoxia-inducible factor 2α (HIF …
2024年9月5日 · Hypoxia-inducible factor 2α (HIF-2α) is a critical transcription factor that regulates cellular responses under hypoxic conditions. In situations of insufficient oxygen supply or …
HIF-1 and HIF-2 in cancer: structure, regulation, and therapeutic ...
2025年1月18日 · In this review, we summarize the similarities and differences between HIF-1α and HIF-2α in their structure, expression, and DNA binding. We also discuss the canonical …
Hypoxia-Inducible Factor 2 Alpha (HIF2α) Inhibitors: Targeting ...
2023年3月4日 · Tumors driven by deficiency of the VHL gene product, which is involved in degradation of the hypoxia-inducible factor subunit 2 alpha (HIF2α), are natural candidates for …
ARNT-dependent HIF-2α signaling protects cardiac ... - Nature
2 天之前 · The cells were then exposed to hypoxic conditions (1% O 2, balanced with 5% CO 2 and 95% N 2) using an InVivo2400 hypoxia workstation (Ruskinn Technologies) for 4 h, with …