In this review, we highlight the studies of CXCR4-targeted small-molecule and peptide HIV-1 entry inhibitors discovered during the last two decades and provide a reference for further potential …

HIV病毒除了需要通过结合 CD4受体 进入人体细胞，还需要两个辅助受体，分别是CCR5和CXCR4. 这两个辅助受体只要存在一个，人体细胞即可能感染艾滋病毒 [1]。 利用何种辅助受体 …

通过与细胞膜上的这两个蛋白质的结合，病毒颗粒将自己固定在cd4+t细胞的表面。因这个缘故，ccr5/cxcr4也被称为hiv的“共受体”（coreceptor，相对于cd4来说）。此 …

2024年12月16日 · 鉴于cxcr4在hiv感染中的核心作用，研发针对cxcr4的抑制剂成为了抗艾滋病药物研发的新方向。 这类药物通过阻断HIV与CXCR4的结合，有效阻止了病毒的入侵，为那些对 …

The identification of CXCR4 as an HIV coreceptor triggered a wide range of research activities to investigate the biological roles of the CXCL12/CXCR4 axis. CXCL12 is a highly conserved …

The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these …

1997年3月4日 · The chemokine receptors CXCR4 and CCR5 function as coreceptors for HIV-1 entry into CD4+ cells. During the early stages of HIV infection, viral isolates tend to use CCR5 …

2022年12月15日 · The human immunodeficiency virus type 1 (HIV-1) recognizes one of its principal coreceptors, the CXC chemokine receptor 4 (CXCR4) on the host cell via the third …

A protein on the surface of certain immune system cells, including CD4 T lymphocytes (CD4 cells). CXCR4 can act as a coreceptor (a second receptor binding site) for HIV when the virus …

The chemokine receptor CXCR4 is required for the entry of human immunodeficiency virus type 1 (HIV-1) into target cells and its expression correlates with more profound pathogenicity, rapid …