GCN2 phosphorylates HIV-1 integrase and decreases HIV-1
2017年5月23日 · GCN2 is a serine/threonine kinase involved in cellular stress response related to amino acid starvation. Previously, we showed that GCN2 interacts with HIV-1 integrase and is activated during...
Activation of GCN2 upon HIV-1 infection and inhibition of
The human protein kinase GCN2 (eIF2AK4) is activated by phosphorylation upon HIV-1 infection in the hours following infection. Thus, infection by HIV-1 constitutes a stress that leads to the activation of GCN2 with a resulting decrease in protein synthesis. We have shown that GCN2 interacts with HIV-1 integrase (IN).
Activation of GCN2 upon HIV-1 infection and inhibition of
2013年2月17日 · In this study, we show that in HIV-1 infected cells, RNA silencing of GCN2 leads to an increase in HIV-1 replication, suggesting that GCN2 has a restriction role in HIV-1 infection. Our results show that infection by HIV-1 constitutes a stress that leads to the activation of GCN2 with the resulting decrease in protein synthesis.
GCN2 is a serine/threonine kinase involved in cellular stress response related to amino acid starvation. Previously, we showed that GCN2 interacts with HIV-1 integrase and is activated during...
HIV Exploits Antiviral Host Innate GCN2-ATF4 Signaling for
2017年5月2日 · In summary, HIV/SIV exploits the early host antiviral response through GCN2-ATF4 signaling by utilizing ATF4 for activating the viral LTR transcription to establish initial viral replication and is a potential target for HIV prevention and therapy.
HIV Exploits Antiviral Host Innate GCN2-ATF4 Signaling for …
2017年5月2日 · Our data showed that early host innate defense against the viral infection involves GCN2-ATF4 signaling-mediated suppression of global protein synthesis, which is exploited by the virus for supporting its own replication during early viral infection and dissemination in …
General control nonderepressible 2 (GCN2) as a therapeutic target …
In this review, we provide a brief overview of GCN2, including its structure, activation mechanisms and interacting partners, and explore its potential significance as a therapeutic target in various age-related diseases including neurodegeneration, inflammatory disorders and cancer.
GCN2 phosphorylates HIV-1 integrase and decreases HIV-1 …
2017年5月23日 · GCN2 is a serine/threonine kinase involved in cellular stress response related to amino acid starvation. Previously, we showed that GCN2 interacts with HIV-1 integrase and is activated during HIV-1 infection.
GCN2 in Viral Defence and the Subversive Tactics ... - ScienceDirect
2024年7月1日 · HIV-1 RNA has also been found to activate GCN2 in vitro. As found above, the GCN2 m2 mutation prevents HIV-1 RNA from eliciting phosphorylation of GCN2 and eIF2α, 75 supporting the idea that HIV-1 RNA also activates GCN2 by binding to the HisRS-like domain.
We report that infection by HIV-1 triggers acute decrease in translation. The human protein kinase GCN2 (eIF2AK4) is activated by phosphorylation upon HIV-1 infection in the hours following infection. Thus, infection by HIV-1 constitutes a stress that leads to the activation of GCN2 with a resulting decrease in protein synthesis.