The human immunodeficiency virus type 1 (HIV-1) p6 protein has recently been recognized as a docking site for several cellular and viral binding partners and is important for the formation of infectious viruses. Most of its known functions are suggested to occur under hydrophobic conditions near the …

2013年2月1日 · The human immunodeficiency virus type 1 (HIV-1) p6 protein serves manifold functions as a docking site for several cellular and viral factors and fulfils important roles in the formation of infectious virus particles.

2024年1月23日 · The incorporation of HIV-1 Vpr into virion is mediated by Gag p6. In the newly infected cells, HIV-1 Vpr promotes viral replication by promoting viral gene transcription, reverse transcription, nuclear transport of the PIC, as well as degradation of host restriction factors.

The p6 domain of human immunodeficiency virus type 1 (HIV-1) is located at the C terminus of the Gag precursor protein Pr55Gag. Previous studies indicated that p6 plays a critical role in HIV-1 particle budding from virus-expressing HeLa cells.

2023年5月30日 · Here, we report that the HIV-1 p6 protein suppresses HIV-1-stimulated expression of IFN-I and promotes immune evasion. Mechanistically, the glutamylated p6 at residue Glu6 inhibits the interaction between STING and tripartite motif protein 32 (TRIM32) or autocrine motility factor receptor (AMFR).

2012年4月1日 · HIV-1 p6 serves manifold functions as docking site for several cellular factors and fulfils important roles in the formation of infectious virus particles. p6 facilitates virus budding [1], [2] and is required for the incorporation of the accessory protein viral protein R (Vpr) into virus particles [3], [4], [5], [6].

The p6 domain of human immunodeficiency virus type 1 (HIV-1) is located at the C terminus of the Gag precursor protein Pr55(Gag). Previous studies indicated that p6 plays a critical role in HIV-1 particle budding from virus-expressing HeLa cells. In this study, we performed a detailed mutational ana …

人类免疫缺陷病毒 1 型 （HIV-1） 中 Gag 前体 （Gag p6） 的 p6 结构域在病毒生命周期中起着多功能作用。 它利用转运所需的内体分选复合物 （ESCRT） 系统，通过与 ESCRT-I 成分肿瘤易感基因 101 （TSG101） 和 ALG-2 相互作用蛋白 X （ALIX） 的相互作用，促进病毒出芽和 ...

2018年6月11日 · HIV-1 Gag harbours a short 52 amino acid peptide p6 at its C-terminus that plays a vital role in virus release form host cell membrane. Two types of motifs have been characterized thus far in...

Group specific antigen, commonly referred to as Gag, is the HIV-1 polyprotein associated with viral structure and infectivity [2]. The 500 amino acid protein comprises four main structural domains (matrix, capsid, nucleocapsid, p6) and two small spacer peptides (SP1 and SP2) that aid in virion formation [2] as shown theoretically in Figure 1 below.