Rev is a transactivating protein that is essential to the regulation of HIV-1 (and other lentiviral) protein expression. A nuclear localization signal is encoded in the rev gene, which allows the Rev protein to be localized to the nucleus, where it is involved in the export of unspliced and incompletely spliced mRNAs.

The nuclear export of intron-containing HIV-1 RNA is critically dependent on the activity of Rev, a virally encoded sequence-specific RNA-binding protein. Rev shuttles between the nucleus and the cytoplasm and harbors both a nuclear localization signal and a nuclear export signal.

Rev蛋白，即调节HIV病毒颗粒蛋白表达的蛋白质 (regulator of expression of virion protein) 。 对HIV调节蛋白有负调控作用，对病毒颗粒蛋白有正调控作用，其主要功能是促进HIV 基因表达 由早期 (转录调节蛋白mRNA)向晚期 (转录HIV结构蛋白mRNA)的转化，并促进晚期转录的进行。 在rev基因缺陷的HIV原病毒，仅有早期基因表达。 只有在加入Rev蛋白后，晚期基因才开始转录。 另外，Rev蛋白还在转运结构蛋白mRNA进入细胞质的过程中发挥作用，这可能是经过在核内抑 …

HIV利用一种跨作用的病毒蛋白Rev和一种顺式作用的RNA二级结构——Rev响应元素（RRE），后者存在于所有保留内含子的病毒mRNAs中，来解决这个问题。 Rev蛋白是由完全剪接过的病毒mRNA持续产生的。

2019年3月26日 · HIV-1 Rev is an essential viral regulatory protein that facilitates the nuclear export of intron-containing viral mRNAs. It is organized into structured, functionally well-characterized motifs...

The HIV-1 Rev response element (RRE) is a ~350 nucleotide, highly structured, cis-acting RNA element essential for viral replication. It is located in the env coding region of the viral genome and is extremely well conserved across different HIV-1 ...

Rev是人類免疫缺陷病毒（HIV）基因组表达的一个早期蛋白，对调控HIV蛋白的表达有重要作用。 Rev蛋白上存在 核定位序列 使其可以输入到 细胞核 ，最终使未剪切的或不完全剪切的mRNA输出细胞核。

HIV-1 Rev is an ~13 kD accessory protein expressed during the early stage of virus replication. After translation, Rev enters the nucleus and binds the Rev response element (RRE), a ~350 nucleotide, highly structured element embedded in the env gene in unspliced and singly spliced viral RNA transcripts. Rev-RNA assemblies subsequently recruit ...

2009年2月3日 · Rev, a key regulatory protein of HIV-1, activates nuclear export of unspliced and partially spliced viral mRNAs, encoding genomic RNA and the structural proteins Gag, Pol, and Env, respectively (reviewed in ref. 1). Rev binds to a highly conserved region of the viral mRNA known as the Rev Response Element (RRE).

While regarded as a canonical RNA export factor, Rev has also been linked to HIV-1 RNA translation, stabilization, splicing and packaging. However, Rev's functions beyond RNA export have remained poorly understood. Here, we revisit this paradigmatic protein, reviewing recent data investigating its structure and function.