研究主要集中在几个方面：直接抑制HK2的合成．这可以通过 RNA干扰 技术来沉寂 基因表达 实现；小分子药物包括Lonidamine可以直接抑制HK的活性．Bifonazol及Clotrimazole通过干扰HK …

Hexokinase II, also known as Hexokinase B and HK2, is an enzyme which in humans is encoded by the HK2 gene on chromosome 2. [5] [6] Hexokinases phosphorylate glucose to produce …

Jan 31, 2018 · Hepatocellular carcinoma (HCC) cells are metabolically distinct from normal hepatocytes by expressing the high-affinity hexokinase (HK2) and suppressing glucokinase …

Dec 25, 2024 · Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the …

Jun 6, 2022 · We discovered that the mitochondrial metabolic enzyme hexokinase 2 (HK2) localizes to the nucleus in leukaemic and normal haematopoietic stem cells. Overexpression …

己糖激酶2（Hexokinase 2, HK2）是催化糖酵解途径中的第一步反应的关键代谢酶，将葡萄糖磷酸化为6-磷酸葡萄糖，主要定位在线粒体外膜上。 HK2在许多肿瘤中都呈现出高表达，在促 …

星状细胞特异性或全身缺失HK2来抑制H3K18la可以减轻星状细胞的激活和肝纤维化。 2023年8月8日，伊利诺伊大学芝加哥分校的Nissim Hay团队在期刊Cell Metabolism（IF:29）发表文章 …

Oct 28, 2024 · Yan et al. report that fructose promotes the progression of colorectal cancer by inhibiting M1-like tumor-associated macrophage polarization. Specifically, fructose functions …

Dec 19, 2022 · By mining large datasets and generating transgenic tools, here we show that hexokinase 2 (HK2), the most active isozyme associated with mitochondrial membrane, is …

己糖激酶 2 (hk2) 是参与糖酵解的关键酶，可将葡萄糖转化为葡萄糖-6-磷酸，在葡萄糖代谢中发挥重要作用。 hk2 可以介导糖酵解，这与炎症因子的释放有关。 hk2的过度表达会增加促炎细胞 …

Mar 16, 2023 · Hexokinase 2 (HK2) plays a multifaceted role in the regulation of cellular activities. A new study by Hu et al.1 delineated a critical role of HK2 in governing glycolytic flux and …

We recently discovered that HK2 facilitates autophagy in response to glucose deprivation (HK substrate deprivation) to protect cardiomyocytes, and suggest that HK2 functions as a …

Jan 15, 2024 · Hexokinase 2 (HK2) is a crucial enzyme involved in glycolysis, which converts glucose into glucose-6-phosphate and plays a significant role in glucose metabolism. HK2 can …

Aug 8, 2023 · Using RNA-seq and CUT&Tag chromatin profiling, we found that induction of hexokinase 2 (HK2) expression in activated HSCs is required for induced gene expression by …

Mar 20, 2023 · 己糖激酶 2 （ Hexokinase 2, HK2 ）是催化糖酵解途径中的第一步反应的关键代谢酶，将葡萄糖磷酸化为 6-磷酸葡萄糖，主要定位在线粒体外膜上。 HK2 在许多肿瘤中都呈现 …

Jan 15, 2024 · Hexokinase 2 (HK2) is a crucial enzyme involved in glycolysis, which converts glucose into glucose-6-phosphate and plays a significant role in glucose metabolism. HK2 can …

Hexokinase-2 (HK2; EC:2.7.1.1) is one of four isozymes of hexokinase in mammalian metabolism that catalyze the first step of glucose metabolism, the conversion of glucose to glucose-6 …

We show that hexokinase 2 (HK2) a metabolic enzyme fuelling cancer cell growth, is a transcriptional target of AHR as well as a modulator of its activity. Expression of HK2 is …

Oct 17, 2014 · Hexokinase catalyzes the phosphorylation of glucose, the rate-limiting first step of glycolysis. Hexokinase II (HK-II) is a predominant isoform in insulin-sensitive tissues such as …

Feb 27, 2025 · Hong Kong authorities can only apply a new pricing model for the HK$2 (25 US cent) transport fare scheme by September of next year because they need time to organise …