这部分结果表明HSC特异性Hk2缺失可减轻造血干细胞中的H3K18la，并抑制肝纤维化，而体内慢性和全身乳酸治疗可恢复胶原沉积和a-SMA表达。 以往研究报道显示成年小鼠的系统性Hk2缺失耐受性良好，可以治疗乳腺癌和肺癌，而且没有不良的生理后果。

2024年12月5日 · 在慢性肾脏疾病（CKD）的背景下，多项研究证实低蛋白饮食（LPD）能有效缓解DKD患者症状，且低蛋白摄入与DKD患者的肾小球滤过率（GFR）和蛋白尿下降密切相关。 有研究指出，高水平的缬氨酸和异亮氨酸可能是DKD发生的风险因素之一。

2023年8月8日 · In this study, we obtained evidence that HK2-induced lactate influences gene expression via histone lactylation and not histone acetylation. We next found that the induction of HK2 expression during HSC activation and the subsequent production of lactate promote histone lactylation at the promoters of genes that are induced during activation.

2021年10月14日 · Mechanistically, combined proteomics and metabolic flux analysis reveals elevated hexokinase 2 (HK2)-driven glycolysis in tumor pericytes, which up-regulates their ROCK2-MLC2 mediated...

近期发表在Cell Metabolism杂志上的一篇题为“Hexokinase2-mediated gene expression via histonel actylation is required for hepatic stellate cell activation and liver fibrosis”的文章中，研究人员证明了HK2诱导的乳酸是通过组蛋白乳酸化而不是组蛋白乙酰化影响基因表达。 研究人员发现在HSC激活的过程中HK2被诱导表达，并且发现随后乳酸的产生促进了诱导其激活过程中基因启动子上的组蛋白乳酸化。

Using RNA-seq and CUT&Tag chromatin profiling, we found that induction of hexokinase 2 (HK2) expression in activated HSCs is required for induced gene expression by histone lactylation but not histone acetylation.

Collectively, we identified that hsa-miR-494-3p, a miRNA induced in both circulation of AKI patients and hypoxia-reoxygenation-treated HK2 cells, enhanced renal inflammation by targeting HtrA3 ...

(A-C)The HK-2 cells under 30 mM glucose (B) or 30 mM glucose+cont siRNA (C) showed a loss of CK and E-cadherin and an increase of a-SMA and vimentin expression compared to that of the cells...

We investigated the effect of PTX3 on cultured human proximal tubular epithelial (HK-2) cells and a rat unilateral ureteral obstruction (UUO) model of renal fibrosis. Method... ...

Yin et al. found that the glycolytic enzyme hexokinase 2 (HK2) was highly abundant in lung fibroblasts from patients with idiopathic pulmonary fibrosis (IPF) and that TGF-β induced the accumulation of HK2 and stimulated glycolysis in mouse and human lung fibroblasts.