Hexokinase III, also known as hexokinase C, is an enzyme which in humans is encoded by the Hk3 gene on chromosome 5. [5][6] Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways.

Mar 30, 2025 · HK3 (Hexokinase 3) is a Protein Coding gene. Diseases associated with HK3 include Long Qt Syndrome. Among its related pathways are glycolysis (BioCyc) and GDP-glucose biosynthesis II. Gene Ontology (GO) annotations related to this gene include enzyme binding and phosphotransferase activity, alcohol group as acceptor.

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May 11, 2022 · We found that HK3 knockout (HK3-null) AML cells showed an accumulation of reactive oxygen species (ROS) as well as DNA damage during ATRA-induced differentiation.

Dec 31, 2024 · HK3 emerges as a novel prognostic biomarker for HCC, exerting regulatory influence over cellular proliferation, metastasis, and invasiveness. These findings indicate that HK3 holds promise as a potential candidate for treatment and prognosis of HCC.

Aug 23, 2024 · HK3 promotes tumor immune evasion by upregulating PD-L1 expression. To elucidate the potential relationship between HK3 and PD-L1, we selected the cell lines as our primary subjects of research.

Hexokinase 3 enhances myeloid cell survival via non-glycolytic functions. Hexokinase 3 dysfunction promotes tumorigenesis and immune escape by upregulating monocyte/macrophage infiltration into the clear cell renal cell carcinoma microenvironment.