基于NK细胞的免疫检查点抑制 - 知乎 - 知乎专栏
HLA-G的表达保护靶细胞免受外周血和NK细胞系中NK细胞毒性的影响。ILT2与HLA-G相互作用也抑制了靶细胞诱导的NK细胞产生极化IFN-γ。可溶性HLA-G（sHLA-G）对NK细 …
HLA Class I Molecules as Immune Checkpoints for NK Cell …
HLA class I molecules are critical regulators of NK cell activation through the interaction with inhibitory- as well as activating NK cell receptors, hence, HLA molecules act as critical …
HLA Class I Molecules as Immune Checkpoints for NK Cell
2021年7月6日 · Natural killer (NK) cells are innate lymphocytes that can kill diseased- or virally-infected cells, mediate antibody dependent cytotoxicity and produce type I immune-associated …
Nat Rev | 肿瘤细胞中的抗原呈递：免疫产生与逃避 - 知乎
hla-e是一种非经典的hla基因，其蛋白产物含有来自其他hla-i分子前导序列的肽，是hla-i表达的传感器，它向nk细胞上的nkg2a和cd8+t细胞提供抑制信号。 这种抑制信号在各类型的癌症中是增 …
NK细胞的HLA和KIR的配型-上篇 - 知乎 - 知乎专栏
NK细胞作为造血干细胞移植后最先重建的固有免疫细胞，有开发成为通用型细胞产品的潜力。 本文从基础HLA和KIR生物学知识开始，回顾分析国外多年积累的临床数据，以期对这一话题进 …
Generation of hypoimmunogenic universal iPS cells through HLA …
4 天之前 · HLA-E blocks NK and CD8 + T cell attacks 31, whereas HLA-G blocks attacks from CD8 + T, CD4 + T, B (ref. 32) and NK cells and macrophages, prompting research into …
Human NK cells: surface receptors, inhibitory checkpoints, and
2019年2月18日 · Human NK cells express two different classes of HLA-class I-specific inhibitory receptors: members of the KIR/CD158 family and the CD94/NKG2A (CD94/CD159a) …
NK Cell Markers: Key Insights in Immunology - BiologyInsights
6 天之前 · Differences in KIR gene content and their corresponding HLA ligands affect NK cell responsiveness, with certain KIR-HLA combinations linked to susceptibility to infections, …
HLA-A alleles influencing NK cell function impact AML relapse …
2020年10月13日 · Using primary NK cells from healthy donors, we demonstrate that HLA-A*23, HLA-A*24, and HLA-A*32 proteins are expressed at different densities and exhibit different …
CAR-NK cell therapy: latest updates from the 2024 ASH annual …
2025年3月1日 · Downregulating human leukocyte antigen (HLA)-ABC expression could reduce the T-cell-mediated destruction on infused CAR-NK cells in vivo, while upregulating HLA E/G, …