The HLA-B gene provides instructions for making a protein that plays a critical role in the immune system. Learn about this gene and related health conditions.

2024年12月25日 · HLA-B (Major Histocompatibility Complex, Class I, B) is a Protein Coding gene. Diseases associated with HLA-B include Spondyloarthropathy 1 and Severe Cutaneous Adverse Reaction. Among its related pathways are SARS-CoV-2 Infection and Infectious disease.

2018年6月5日 · During the course of a workup for possible autoimmune arthritis or autoimmune back disease, your rheumatologist may order something called a HLA-B27 test. So what does a positive HLA-B27 mean? HLA-B27 is a genetic test. The majority of people who have a positive HLA-B27 are perfectly healthy.

HLA-B*27, HLA-B*38, HLA-B*39 and HLA-C*12 alleles are potential psoriatic arthritis-specific genetic markers among patients with psoriasis. HLA-B54 and HLA-A11 were positively associated with diffuse panbronchiolitis in Northern and Southern Chinese, respectively.

The human leukocyte antigen (HLA) system (the major histocompatibility complex [MHC] in humans) is an important part of the immune system and is controlled by genes located on chromosome 6.

The HLA-B gene provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria.

Peripheral blood lymphocytes (PBLs) express HLA class I antigens and are used for the serologic typing of HLA-A, HLA-B, and HLA-C. HLA class II typing is done with B lymphocytes isolated from PBLs because these cells express class II molecules.

Ultimately, at the organismal level, the polymorphisms link to protection from or association with disease. This review will summarize the recent literature which examines all these aspects of the biology of HLA-B, the most polymorphic of the HLA-I genes.

HLA-B*15:02 and HLA-A*31:01 gene variants have been implicated in the development of life-threatening cADRs with several aromatic anticonvulsants that have indications for use in psychiatry.

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. Host determinants of HIV-1 control in African Americans. Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the …