HLA-B (major histocompatibility complex, class I, B) is a human gene that provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex.

2024年12月25日 · HLA-B (Major Histocompatibility Complex, Class I, B) is a Protein Coding gene. Diseases associated with HLA-B include Spondyloarthropathy 1 and Severe Cutaneous Adverse Reaction. Among its related pathways are SARS-CoV-2 Infection and Infectious disease.

The HLA-B gene provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria.

2016年8月19日 · HLA-B is a gene/antigen in the HLA system. There are hundreds of alleles, with many similar variants grouped together, that form subtypes HLA-B*2701 to HLA-B*2763. The genotype is connected with immunity and autoimmune diseases, specifically autoimmune forms of arthritis. Two commonly tested tag SNPs for HLA-B27 are rs13202464 and rs4349859.

Gene ID: 3106, updated on 9-Feb-2025. HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane.

2025年1月5日 · HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen.

The HLA-B gene provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria.

HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. Host determinants of HIV-1 control in African Americans. Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the …

This gene has 7 transcripts (splice variants), 1 gene allele, 9 paralogues and is associated with 9 phenotypes.

2016年9月14日 · The HLA-B gene provides instructions for making a protein that plays a critical role in the immune system. HLA-B is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria.