HLA-DM (human leukocyte antigen DM) is an intracellular protein involved in the mechanism of antigen presentation on antigen presenting cells (APCs) of the immune system. [2] It does this …

HLA研究中，模拟免疫反应激活的过程，就要经过 蛋白酶体对抗原（蛋白）的剪切预测 、肽段转运、 肽段和MHC-I结合亲和力预测 以及 T细胞识别预测 等几个重要步骤。 一般可以采用滑动 …

Peptide loading of class II MHC molecules in endosomal compartments is regulated by HLA-DM. HLA-DO modulates HLA-DM function, with consequences for the spectrum of MHC-bound …

HLA-DM, a variant of the HLA Class II molecules, is a type of molecule encoded on chromosome 6 that plays a crucial role in presenting peptides from outside the cell and interacting with …

HLA-DO modulates HLA-DM function, with consequences for the spectrum of MHC-bound epitopes presented at the cell surface for interaction with T cells. Here, we summarize and …

Antigen presentation by major histocompatibility complex class II molecules (MHC II) to CD4+ T cells plays a key role in the regulation of the adaptive immune response. Loading of antigenic …

2012年3月2日 · HLA-DM plays an essential role in the peptide loading of classical class II molecules and is present both at the cell surface and in late endosomal peptide-loading …

2015年7月15日 · Removal of CLIP from MHC II and loading of antigenic peptides to MHC II are catalyzed by DM (HLA-DM in humans and H2-M in mice) (7–10). Peptide-loaded MHC II …

1999年4月1日 · HLA-DM is the first example of a molecular chaperone that operates in lysosomes: it plays a crucial role in endosomal and lysosomal compartments during loading of …

HLA-DM has three main functions: it causes the dissociation of CLIP from the peptide binding groove of MHC II, stabalizes and prevents degradation of the empty MHC II, and facilitates the …