Human leukocyte histocompatibility complex DO (HLA-DO) is an intracellular, dimeric non-classical Major Histocompatibility Complex (MHC) class II protein composed of α-and β …

HLA -II型 （HLA-DP, HLA-DM, HLA-DO, HLA-DQ, HLA-DR）编码第二型MHC，将细胞外抗原呈递给CD 4+ T（T-helper cells 辅助T细胞），T细胞增殖，进而刺激B细胞产生抗原特异性抗 …

HLA-DO modulates HLA-DM function, with consequences for the spectrum of MHC-bound epitopes presented at the cell surface for interaction with T cells. Here, we summarize and …

Here, we review published work on the discovery and function of a MHC class II molecular chaperone, HLA-DO, in human, and its mouse analog H2-O, herein called DO. While DO was …

The activity of HLA-DO skews peptide loading to the late endosomal structures where B cell receptormediated antigens are processed. HLA-DO may thus play a critical role in controlling …

人体中编码MHC的基因在第6号染色体上，又称 HLA （human leukocyte antigen）。 MHC是在器官移植过程中被发现的：从小鼠身上移植器官到不同品系小鼠上会发生排异反应，而决定是否 …

Comprehensive analysis of MHC-II immunopeptidomes from cells lacking DO (human HLA-DO or murine H2-O) shows that DO controls the diversity of the MHC-II peptide repertoire. DO …

篇首： HLA-DM和HLA-DO同属于HLA-Ⅱ类相关抗原加工递呈基因,又被称作HLA-Ⅱb类分子.在获得性免疫中,DM分子通过形成二聚体复合物参与肽交换以及Ⅱ类经典分子荷肽(Peptide-loading …

1998年2月12日 · Recent studies have revealed that the conserved major histocompatibility complex class II molecule, HLA-DO, inhibits the class II antigen-processing pathway. HLA-DO, …

HLA-DO modulates HLA-DM function, with consequences for the spectrum of MHC-bound epitopes presented at the cell surface for interaction with T cells. Here, we summarize and …