HMGA2 contains three basic DNA-binding domains (AT-hooks) that cause the protein to bind to adenine - thymine (AT)-rich regions of nuclear DNA. HMGA2 does not directly promote or …

2024年12月25日 · HMGA2 (High Mobility Group AT-Hook 2) is a Protein Coding gene. Diseases associated with HMGA2 include Silver-Russell Syndrome 5 and Salivary Gland Adenoma, …

有研究已证实高迁移率族蛋白A2（HMGA2）基因是一种新的癌基因，且其表达的HMGA2蛋白促进肿瘤增殖、侵袭，有望成为一种新的基因治疗靶点，然而关于其致癌的发病机制以及HMGA2 …

2023年10月12日 · Here we show that HMGA2 mediates direct condensation of polynucleosomes and forms droplets with nucleosomes. Consistently, most endogenous HMGA2 localized to …

HMGA2 increases cancer cell proliferation by promoting cell cycle entry and inhibition of apoptosis. In addition, HMGA2 influences different DNA repair mechanisms and promotes …

HMGA2 is an important biomarker to predicting nasopharyngeal carcinoma patient's survival time. HMGA2 is predominantly amplified and expressed in AML cells, and that aberrant expression …

HMGA (high mobility group A) (HMGA1 and HMGA2) are small non-histone proteins that can bind DNA and modify chromatin state, thus modulating the accessibility of regulatory factors to the …

2024年3月16日 · HMGA2 binds and promotes cis-element modification in the promoter region of the GPX4 gene by enhancing enhancer activity through increased H3K4 methylation and …

HMG 蛋白作为结构因子发挥作用，是增强体的重要组成部分。 该蛋白质包含结构 DNA 结合域，可作为转录调节因子。 鉴定与粘液样脂肪肉瘤相关的该基因的缺失、扩增和重排表明其在 …

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and minor groove of adenine-thymine-rich DNA binding activity. Involved in several processes, including …