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ML356 (Compound 16) is an inhibitor for fatty acid synthase (FAS), that inhibits the thioesterase domain of FAS (FAS TE) with an IC 50 of 0.334 μM, and blocks the de novo palmitate synthesis in PC-3 cell with an IC 50 of 20 μM. ML356 exhibits good membrane permeability, and good stability in human and mouse plasma.

ML356 (Compound 16) 是脂肪酸合酶 (FAS) 的抑制剂，可抑制 FAS 的硫酯酶结构域 (FAS TE)，IC 50 为 0.334 μM，并可阻断 PC-3 细胞中的棕榈酸从头合成， IC50 为 20 μM。 ML356 表现出良好的膜通透性，并在人和小鼠血浆中表现出良好的稳定性。 [1]. Cosford N, et al., Small molecule fatty acid synthase inhibitors. WO2015134790.

ML-356 is an inhibitor of the thioesterase domain of fatty acid synthase (FASN-TE; IC 50 = 334 nM). 1 It is selective for FASN over a number of other human thioesterases expressed in tumor cells, and selective for FASN-TE over its most closely related human homolog, ACOT4. 1 In cells, ML-356 has been shown to block the biosynthesis of palmitate,...

2013年4月12日 · ML356, the lead compound from this series, is potent (IC 50 = 0.334 μM) and selective inhibitor of FAS-TE. The compounds are selective for FAS over a number of other human thioesterases expressed in tumor cells, and selective for the thioesterase domain of FAS over its most closely related human homolog, ACOT4.

ML356: 一种FAS抑制剂药物，由Sanford Burnham Prebys Medical Discovery Institute (桑弗伯纳姆普理贝斯医学探索研究所)公司最早进行研发，目前全球最高研发状态为临床前，作用机制: FAS抑制剂(脂肪酸合成酶抑制剂)，在研机构: Sanford Burnham Prebys …

ML356, the lead compound from this series, is potent (IC 50 = 0.334 μM) and selective inhibitor of FAS-TE. The compounds are selective for FAS over a number of other human thioesterases expressed in tumor cells, and selective for the thioesterase domain of FAS over its most closely related human homolog, ACOT4.

ML356 (Compound 16) is an inhibitor for fatty acid synthase (FAS), that inhibits the thioesterase domain of FAS (FAS TE) with an IC50 of 0.334 μM, and blocks the de novo palmitate synthesis in PC-3 cell with an IC50 of 20 μM. ML356 exhibits good membrane permeability, and good stability in human and mouse plasma[1]. [1].

ML356 is a selective inhibitor of FAS-TE. It act as an inhibitor of the thioesterase domain of fatty acid synthase.