2024年12月25日 · HOXA1 (Homeobox A1) is a Protein Coding gene. Diseases associated with HOXA1 include Athabaskan Brainstem Dysgenesis Syndrome and Bosley-Salih-Alorainy Syndrome . Among its related pathways are RNA Polymerase I Promoter Opening and Nervous system development .

Homeobox protein Hox-A1 is a protein that in humans is encoded by the HOXA1 gene. [5][6][7] Two transcript variants encoding two different isoforms have been found for this gene, with only one of the isoforms containing the homeodomain region. [8]

2022年7月1日 · HOXA1 is one of the first HOX genes expressed in the gastrulating mammalian embryo. HOXA1 plays roles in the anterior part of developing organism. It is essential to the segmentation of the hindbrain, and provides the identity to the rhombomeres, the hindbrain territories [47, 48].

HOXA1-4 genes have participated in the regulation of gene expression related to the heart, blood vessels, viruses, genetic diseases, neurology, psychiatry, and developmental defects. In recent years, several studies have provided evidence of the involvement of HOXA1 expression in heart disease, particularly in congenital heart defects (CHD) .

2024年11月14日 · HOXA1-related disorders are characterized by ocular motility disorder (horizontal gaze palsy with or without Duane syndrome), bilateral sensorineural deafness, cerebrovascular malformations (predominantly involving the carotid arteries), motor delay, central hypoventilation, and intellectual disability.

By analyzing data from The Cancer Genome Atlas (TCGA), we found that HOXA1 was aberrantly upregulated in multiple cancers, and that elevated HOXA1 was significantly associated with poor prognosis of post-radiotherapy head and neck squamous cell carcinoma (HNSCC) and low-grade glioma (LGG) patients.

2025年2月8日 · Title: HOXA1 silencing inhibits cisplatin resistance of oral squamous cell carcinoma cells via IκB/NF-κB signaling pathway. A poly-histidine motif of HOXA1 is involved in regulatory interactions with cysteine-rich proteins.

Our in vitro data showed that knockdown of HOXA1 attenuated the growth, invasion and migration of prostate cancer DU-145 and PC-3 cells. Furthermore, knockdown of HOXA1 resulted in an increased E-cadherin level and decreased Snail and MMP-3 levels in the DU-145 cells.

HOXA1 is a downstream effector of E-cadherin-directed signaling required for anchorage-independent proliferation of mammary carcinoma cells. HOXA1 A218G alleles significantly influence head growth rates, but not final head size, in normal human development. Study reveals the preferential expression of HOXA1 by metaphase II oocytes.

Homeobox A1 (HOXA1) serves an oncogenic role in multiple cancer types. However, the role of HOXA1 in non‑small cell lung cancer (NSCLC) remains unclear. In the present study, use of reverse transcription-quantitative polymerase chain reaction and the databases of The Cancer Genome Atlas (TCGA), Onco …