Crystal Structure of an HSA/FcRn Complex Reveals Recycling by ...
2013年11月5日 · Using yeast display, we identified human serum albumin (HSA) variants with increased affinity for human FcRn at endosomal pH, enabling us to solve the crystal structure …
A human endothelial cell-based recycling assay for screening of …
2018年2月12日 · Here, we report on a novel human endothelial cell-based recycling assay (HERA) that can be used for such pre-clinical screening. In HERA, rescue from degradation …
Human and mouse albumin bind their respective neonatal Fc
2018年10月2日 · In the current study, we aimed to investigate how differences in the amino acid composition of DI between MSA and HSA affect receptor binding. We found that targeting …
Crystal structure of an HSA/FcRn complex reveals recycling by ...
2013年11月5日 · The long circulating half-life of serum albumin, the most abundant protein in mammalian plasma, derives from pH-dependent endosomal salvage from degradation, …
human serum albumin (HSA) variants with increased affinity for human FcRn at endosomal pH, enabling us to solve the crystal structure of a variant HSA/ FcRn complex. We find an …
mAbs发表双抗、三抗新结构——TrYbe，无Fc段延长半衰|半衰期
2023年2月24日 · 为了延长体内半衰期，TrYbe®的一个靶标结合结构域被设计为人血清白蛋白 （HSA） 特异性，HSA延长半衰期的主要机制和FcRn介导的HSA回收有关。 TrYbe®分子另外 …
The neonatal Fc receptor, FcRn, as a target for drug delivery and ...
2015年8月30日 · The ~ 300-fold increased affinity for FcRn at pH 6 translated to an ~ 1.5 fold increase in HSA half-life in monkeys. These studies validate the role of FcRn in regulating …
高效产生的 DARPin 血清白蛋白融合物的半衰期延长与 FcRn 亲和 …
由于人血清白蛋白 (HSA) 不与鼠 FcRn 结合，因此经常在人 FcRn 转基因小鼠中测量候选治疗剂的半衰期，从而限制了可用的肿瘤模型。 此外，还设计了具有延长半衰期的血清白蛋白。
Structural Insights into Neonatal Fc Receptor-based Recycling ...
We report the three-dimensional structure of human neonatal Fc receptor (FcRn) bound concurrently to its two known ligands. More particularly, we solved the crystal structure of the …
FcRn的套路，延长抗体半衰期 - 知乎 - 知乎专栏
FcRn (neonatal Fc receptor for IgG)是由 FCGRT (Fc fragment of IgG receptor and transporter) 基因编码的α重链与胞外 β2-微球蛋白 （β2m）轻链非共价结合构成的异二聚体。 重链包括三个 …