Dysregulated haematopoietic stem cell behaviour in myeloid ... - Nature
2020年5月15日 · Haematopoiesis is governed by haematopoietic stem cells (HSCs) that produce all lineages of blood and immune cells. The maintenance of blood homeostasis requires a …
HSC commitment-associated epigenetic signature is prognostic …
Acute myeloid leukemia (AML) is characterized by disruption of HSC and progenitor cell differentiation. Frequently, AML is associated with mutations in genes encoding epigenetic …
Leukemia：胡绍燕团队揭示细胞起源如何影响急性髓系白血病预后…
2024年11月5日 · 该研究发现，在HSC起源的白血病转化过程中，这些表观遗传程序被部分保留，与癌基因（MLL::AF9易位）驱动的程序协同作用，这种结合效应导致HSC起源的AML的侵 …
c-JUN interacts with HDAC1 as a potential combinatorial …
2025年1月27日 · HDAC1 is a key oncogene in AML, linked to prognosis. c-JUN activity is elevated in AML progenitor cells and is associated with HDAC1 expression. Inhibiting c-JUN …
Hematopoietic versus leukemic stem cell quiescence: Challenges …
2021年11月1日 · HSC quiescence is carefully controlled by both intrinsic and extrinsic, niche-driven mechanisms. In acute myeloid leukemia (AML), the leukemic cells overtake the …
Oxidative stress and hypoxia in normal and leukemic stem cells
2016年7月1日 · Hematopoietic stem cells (HSCs) are localized to hypoxic niches in bone marrow. Hypoxia-inducible factors play key roles in the maintenance of HSCs. HSCs display peculiar …
Normal hematopoietic stem cells within the AML bone marrow …
2013年11月11日 · LSC and normal hematopoietic stem cells (HSC) share many characteristics and co-exist in the bone marrow of AML patients. For the development of successful LSC …
Identification of leukemic and pre-leukemic stem cells by clonal ...
2021年3月1日 · Here, we demonstrate that LSCs, HSCs, and pre-leukemic stem cells can be identified and molecularly profiled by combining single-cell transcriptomics with lineage tracing …
c-JUN interacts with HDAC1 as a potential combinatorial
2025年1月27日 · We identified the activity of c-JUN is specifically enhanced in HSC-Prog in AML patients. We suggest a potential regulatory relationship between c-JUN and HDAC1 in AML …
Hematopoietic stem cell transplantation for patients with AML …
2016年1月7日 · Here, we address 3 important issues in the field of postremission therapy by alloHSCT or autoHSCT in first complete response (CR1) in patients with AML: What is the …
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