Heat shock factor 1 (HSF1) specifically potentiates c-MYC …
2023年6月27日 · Here, we show that heat shock factor 1 (HSF1), the master transcriptional regulator of the heat shock response, acts as a prime modifier of the c-MYC-mediated …
Heat shock factor protein 1 - Wikipedia
The HSF1 protein regulates the heat shock response (HSR) pathway in humans by acting as the major transcription factor for heat shock proteins. The HSR plays a protective role by ensuring …
HSF1 phosphorylation establishes an active chromatin state via …
2022年7月29日 · We examined effects of reduced histone acetylation on the interaction between the TRIM proteins and HSF1, and found that TRRAP KD or TIP60 KD reduced co-precipitation …
HSF1 Gene - GeneCards | HSF1 Protein | HSF1 Antibody
2024年12月25日 · Complete information for HSF1 gene (Protein Coding), Heat Shock Transcription Factor 1, including: function, proteins, disorders, pathways, orthologs, and …
Nature Cell Biology：揭示HSF1的可诱导和可逆相分离介导热休克 …
基于热休克期间hsf1的翻译后修饰（ptm）调控其转录活性的报道，作者通过构建一系列突变体和体外磷酸化hsf1，阐明了特定位点的ptm驱动hsf1相分离。 为了进一步探究HSF1相分离对转 …
HSF1 phase transition mediates stress adaptation and cell fate ... - Nature
2020年2月3日 · Here we report that condensation and phase transition of heat-shock factor 1 (HSF1), a transcriptional regulator of chaperones 1, 2, is integral to cell-fate decisions …
Protein Kinase A Binds and Activates Heat Shock Factor 1
2010年11月9日 · In a proteomic study of HSF1 binding partners, we have discovered its association with the pleiotropic protein kinase A (PKA). HSF1 binds avidly to the catalytic …
谱绘细胞内的“冰与火之歌”：揭开HSF1调控热休克过程的神秘面纱
2022年3月9日 · 该机制揭示了HSF1活性的动态调节过程，即在急性应激期间有效驱动HSPs基因转录并在热休克停止后适时终止转录，维持细胞内蛋白质稳态。 基于HSF1的动态调控谱绘了细 …
MED12 interacts with the heat‐shock transcription factor HSF1 …
2021年5月31日 · We herein demonstrated that HSF1 interacted with MED12 and recruited MED12 and CDK8 to the HSP70 promoter during heat shock in mammalian cells. The kinase …
Heat shock factor 1 (HSF1) specifically potentiates c-MYC …
2023年6月27日 · To determine the necessity of HSF1, we examined the expression of c-MYC target genes in immortalized mouse embryonic fibroblasts (MEFs) following transient Hsf1 …