Secreted heat shock protein gp96-Ig: next-generation vaccines for ...
Over the past decade, our laboratory has developed a secreted heat shock protein (HSP), chaperone gp96, cell-based vaccine that generates effective anti-tumor and anti-infectious …
Secreted heat shock protein gp96-Ig: an innovative vaccine
HSP gp96 also known as glucose-regulated protein grp94, is the primary chaperone of the endoplasmatic reticulum. Gp96/grp94, because of its peptide chaperone capacity and its …
孟颂东团队发现热休克蛋白gp96驱动NK细胞的发育成熟和肿瘤抑 …
2024年2月21日 · 该团队利用gp96细胞特异性敲除的小鼠模型，发现gp96蛋白对于 自然杀伤细胞 （NK细胞）对肿瘤的杀伤功能、产生 IFN-γ 能力、对 IL-15 的反应性至关重要，敲除gp96后 …
Induction of Foxp3 and activation of Tregs by HSP gp96 for ... - PubMed
2021年11月17日 · Immunization of gp96 increased Treg frequency, expansion, and suppressive function. Gene expression profiling identified the NF-κB family member p65 and c-Rel as the …
HSPs drive dichotomous T-cell immune responses via DNA
2017年5月31日 · Immunization with low doses of gp96 primes T helper type 1 (Th1) immune responses, whereas high-dose immunization primes responses characterized by regulatory T …
原中国工程院院士卢世璧教授及301医院骨科研究所团队刊文将热休克蛋白GP70、GP96 …
2024年10月28日 · hsp的2 种亚型，hsp70及gp96具有抗原递呈作用，即在细胞内将抗 原与mhc结合，并递呈到细胞表面，从而活化t细胞，包括 cd4+和cd8+t细胞，特别是细胞毒性杀伤细 …
The heat shock protein gp96: a receptor-targeted cross-priming …
Heat shock proteins like gp96 (grp94) are able to induce specific cytotoxic T-cell (CTL) responses against cells from which they originate and are currently studied in clinical trials for use in …
Secreted heat shock protein gp96-Ig: next-generation vaccines for ...
2013年11月20日 · Here, we review the vaccine design that utilizes the unique property/ability of endoplasmic HSP gp96 to bind antigenic peptides and deliver them to antigen-presenting …
Treg suppress CTL responses upon immunization with HSP gp96
2009年10月30日 · In mouse models, gp96–peptide complexes have been shown to prime and induce MHC class I-restricted CTL responses by cross-presentation of peptides to MHC class …
The HSP GRP94 interacts with macrophage intracellular ... - Nature
2021年1月22日 · Glucose-regulated protein 94 (GRP94, also known as Gp96) is an endoplasmic reticulum (ER) member of the heat shock protein HSP90 family whose expression is...