Hsp27 is a chaperone of the sHsp (small heat shock protein) group among α- crystallin, Hsp20, and others. The common functions of sHsps are chaperone activity, thermotolerance, inhibition of apoptosis, regulation of cell development, and cell differentiation. They also take part in …

Heat shock protein 27 (HSP27) is a multidimensional protein which acts as a protein chaperone and an antioxidant and plays a role in the inhibition of apoptosis and actin cytoskeletal remodeling. In each of these capacities, HSP27 has been implicated in different disease states playing both protective and counter-protective roles.

热休克蛋白27（HSP-27），属于低分子量热休克蛋白家族的成员，Hsp27是一个涉及到药物抗性、细胞生长、细胞凋亡、肿瘤的发生和转移等功能的重要蛋白，Hsp27介导的这些功能可能与其对其它蛋白质的影响有关。

2020年3月30日 · Here, we find that human small heat-shock protein 27 (Hsp27), a canonical chaperone that localizes to stress granules (SGs), prevents FUS from undergoing liquid−liquid phase separation (LLPS) via...

The small heat‐shock protein of 27 kDa (HSP27) is highly expressed in many cancers and is associated with aggressive tumour behaviour, metastasis, poor prognosis and resistance to chemotherapy. We aimed at assessing the role of HSP27 in modulating ...

Heat shock protein 27 (HSP27) is a small chaperone protein that is overexpressed in a variety of cellular stress states. It is involved in regulating proteostasis and protecting cells from multiple sources of stress injury by stabilizing protein conformation and promoting the refolding of misfolded proteins.

Heat shock proteins are important for maintaining protein homeostasis and cell survival. Among different classes of highly conserved Hsps, low molecular weight Hsps (sHsps) have significant place, particularly Hsp27, whose role has been demonstrated in wide range of biological processes, including d …

2023年9月26日 · Using an unbiased proteomics approach, we find that the small heat shock protein 27 (Hsp27) interacts specifically with CerS1 but not other CerS. Functionally, our data show that Hsp27 acts as an endogenous inhibitor of CerS1. Wild-type Hsp27, but not a mutant deficient in CerS1 binding, inhibits CerS1 activity.

2017年10月1日 · Hsp27 exists as a multimeric complex in the cells and serves functions, like refolding of unfolded proteins, regulation of cytoskeleton dynamics as well as cell cycle regulation. sHsps bind to a wide range of cellular proteins and are implicated in several cellular functions, apart from providing protection against various environmental and ...

2014年12月1日 · We further predicted 17 newly described Hsp27 cellular functions based on its presence in functional modules such as DNA repair as well as RNA splicing, two processes for which we uncovered and experimentally validated the involvement Hsp27 in CRPC cells, supporting our system biology predicted functions, and providing new insights into Hsp27 ...