Heat shock protein 47, also known as SERPINH1 is a serpin which serves as a human chaperone protein for collagen. [5][6] This protein is a member of the serpin superfamily of serine …

2016年11月14日 · Hsp47识别三螺旋原胶原蛋白上的胶原蛋白（Gly-Xaa-Arg）重复序列，可以防止原胶原蛋白的局部展开和/或聚集。 小鼠Hsp47的基因破坏由于基底膜受损和胶原原纤维形 …

Expert opinion: As a collagen-specific chaperon, HSP47 is a promising therapeutic target in fibrosis. Preclinical models have shown encouraging anti-fibrotic results. Anti-HSP47 …

Hsp47 is a heat-shock protein that interacts transiently with procollagen during its folding, assembly and transport from the endoplasmic reticulum (ER) of mammalian cells. It has been …

2023年11月11日 · Here, we identify HSP47, a collagen-specific chaperone, as a key determinant of body adiposity. HSP47 expression is abundant in adipose tissue; increased with feeding, …

2018年12月12日 · Heat shock protein 47 (Hsp47) is an endoplasmic reticulum (ER)-resident molecular chaperone essential for correct folding of procollagen in mammalian cells. In this …

Heat shock protein (HSP) 47 is a 47 kDa collagen-binding glycoprotein localized in the endoplasmic reticulum (ER). It belongs to the serpin family and contains a serpin loop, …

Hsp47, a collagen-specific molecular chaperone that localizes in the endoplasmic reticulum (ER), is indispensable for molecular maturation of collagen. Hsp47, which is encoded by the …

2020年2月7日 · 通过癌症基因组图谱（tcga）人类乳腺癌数据集中的基因表达谱分析，研究者发现hsp47（serpinh1）的mrna水平与emt调节剂和emt标记物的含量显著相关，提示hsp47参与激 …

Heat shock protein 47 (Hsp47) is a procollagen/collagen-specific molecular chaperone protein derived from the serpin family of proteins and essential for the early stages of collagen …