于是作者通过测量 Xbp1s （由IRE1介导的剪接Xbp1转录本）和Hspa5（ATF6目标基因）的总体种群水平表达来监测IRE1和ATF6的活性。研究人员验证了Xbp1s和Hspa5在Tm处理开始后的12和15小时最大程度地诱导，并在24小时后显着降低。

2024年12月25日 · The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins in the ER and is a master regulator of ER homeostasis.

2024年3月30日 · Endoplasmic reticulum (ER) stress-related genes are closely related to the occurrence, development, and immunotherapy response of tumors. This study provides a comprehensive assessment of HSPA5 from a pan-cancer perspective using multi-omics data. We analyzed the function of HSPA5 in multiple tumor types using multiple databases.

2017年6月30日 · The HSPA5 gene encodes the binding immunoglobulin protein (BiP), an Hsp70 family chaperone localized in the ER lumen. As a highly conserved molecular chaperone, BiP assists in a wide range of folding processes via its two structural domains, a nucleotide-binding domain (NBD) and substrate-binding do …

2017年6月30日 · The HSPA5 gene encodes the binding immunoglobulin protein (BiP), an Hsp70 family chaperone localized in the ER lumen. As a highly conserved molecular chaperone, BiP assists in a wide range of folding processes via its two structural domains, a nucleotide-binding domain (NBD) and substrate-binding domain (SBD).

HSPA5 is also known as GRP78 or BIP, and it localizes to the lumen of the endoplasmic reticulum (ER). HSPA5 is involved in protein folding and assembly as a molecular chaperone of HSP70 in the ER and regulates ER homeostasis . HSPA5 participates in ER stress by interacting with S100 calcium-binding protein 16 and activating IRE1α ...

2023年5月8日 · Heat shock protein family A (Hsp70) member 5 (HSPA5) is an endoplasmic reticulum chaperone, which regulates cell metabolism, particularly lipid metabolism. While HSPA5’s role in regulating cell...

2022年7月14日 · Objective: This study aimed to evaluate the associations between endoplasmic reticulum (ER) stress-related genes EIF2AK3/PERK, HSPA5/GRP78, and DDIT3/CHOP polymorphisms and the risk of lung cancer. Methods: Six single-nucleotide polymorphisms (SNPs) of EIF2AK3, HSPA5, and DDIT3 were genotyped in 620 cases and 620 controls using a MassARRAY ...

HSPA5, alternatively referred to as glucoseregulated protein 78 kDa (GRP78) or binding immunoglobulin Protein (BiP), is a constituent of the heat shock protein 70 (HSP70) family and functions as a vital molecular chaperone in the endoplasmic reticulum (ER). This protein is implicated in various critical cellular processes.

2023年6月1日 · Heat Shock Protein Family A (Hsp70) Member 5 (HSPA5, also called GRP78 or BIP), localized to the lumen, is involved in protein folding and assembly in the endoplasmic reticulum (ER) as a canonical HSP70 chaperone and is …